Roflumilast-d4

Name: Roflumilast-d4
Brand: Vaqora Chemicals
SKU: VQ-041987

About Roflumilast-d4

Vaqora Chemicals supplies Roflumilast-d4, a stable isotope labelled analogue related to Roflumilast registered under CAS number 1398065-69-4. Formula C17H14Cl2F2N2O3, molecular weight 407.2 g/mol. Systematically, it is named N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-[(2,2,3,3-tetradeuteriocyclopropyl)methoxy]benzamide. It is also known as Roflumilast-d4 (cyclopropyl-2,2,3,3-d4).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Roflumilast and related analytes in bioanalytical, pharmacokinetic and impurity studies. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Roflumilast-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Roflumilast-d4
Catalogue No.	VQ-041987
CAS Number	1398065-69-4
IUPAC name	N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-[(2,2,3,3-tetradeuteriocyclopropyl)methoxy]benzamide
Molecular formula	C₁₇H₁₄Cl₂F₂N₂O₃
Molecular weight	407.2 g/mol
Exact mass	406.0601
Grade	Reference Standard
HSN code	38229090
InChIKey	MNDBXUUTURYVHR-LNLMKGTHSA-N
SMILES	[2H]C1(C(C1([2H])[2H])COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F)[2H]
PubChem CID	71752096

Physical properties
Physical form	Solid
LogP (XLogP3)	4.6
H-bond donors / acceptors	1 / 6
TPSA	60.5 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Roflumilast-d4?

The CAS Registry Number of Roflumilast-d4 is 1398065-69-4. It is also known as Roflumilast-d4 (cyclopropyl-2,2,3,3-d4), 3-(Cyclopropyl-d4)methoxy-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide.

What is the molecular formula and molecular weight of Roflumilast-d4?

Roflumilast-d4 has the molecular formula C17H14Cl2F2N2O3 and a molecular weight of 407.2 g/mol. Its IUPAC name is N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-[(2,2,3,3-tetradeuteriocyclopropyl)methoxy]benzamide.

What is Roflumilast-d4 used for?

Roflumilast-d4 is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Roflumilast-d4 can I order?

We supply Roflumilast-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Roflumilast-d4?

Yes. Every lot of Roflumilast-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Roflumilast-d4 be shipped internationally?

Yes. We export Roflumilast-d4 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.