32-O-Demethyl-rapamycin

About 32-O-Demethyl-rapamycin

32-O-Demethyl-rapamycin is a metabolite or degradation product of Rapamycin carrying the CAS registry number 141392-23-6. Formula C50H77NO13, molecular weight 900.1 g/mol. It is also known as 27-O-Desmethyl Rapamycin or Rapamycin, 32-O-demethyl-.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Rapamycin, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Rapamycin

View every impurity, metabolite and intermediate we list for Rapamycin.

Rapamycin impurities

Specifications & identifiers

Chemical identifiers
Product name	32-O-Demethyl-rapamycin
Catalogue No.	VQ-042189
CAS Number	141392-23-6
IUPAC name	(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18,19-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-30-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Molecular formula	C₅₀H₇₇NO₁₃
Molecular weight	900.1 g/mol
Exact mass	899.5395
Grade	Reference Standard
HSN code	38229090
InChIKey	FQQYOXPFBMYCPO-AURGRMCHSA-N
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)O)C)C)/C)OC
PubChem CID	9811509

Physical properties
Physical form	Solid
LogP (XLogP3)	5.5
H-bond donors / acceptors	4 / 13
TPSA	206 Å²
Synonyms	27-O-Desmethyl Rapamycin, Rapamycin, 32-O-demethyl-, Rapamycin, 32-O-demethyl-(9CI), 32-Desmethylrapamycin, 27-O-Demethylrapamycin, 27-O-Desmethyl Rapamycin (27-O-Desmethyl Sirolimus)

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H341Suspected of causing genetic defects

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 32-O-Demethyl-rapamycin?

The CAS Registry Number of 32-O-Demethyl-rapamycin is 141392-23-6. It is also known as 27-O-Desmethyl Rapamycin, Rapamycin, 32-O-demethyl-, Rapamycin, 32-O-demethyl-(9CI).

What is the molecular formula and molecular weight of 32-O-Demethyl-rapamycin?

32-O-Demethyl-rapamycin has the molecular formula C50H77NO13 and a molecular weight of 900.1 g/mol.

What is 32-O-Demethyl-rapamycin used for?

32-O-Demethyl-rapamycin is supplied as a characterised reference material related to Rapamycin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 32-O-Demethyl-rapamycin can I order?

We supply 32-O-Demethyl-rapamycin in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 32-O-Demethyl-rapamycin?

Yes. Every lot of 32-O-Demethyl-rapamycin is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 32-O-Demethyl-rapamycin be shipped internationally?

Yes. 32-O-Demethyl-rapamycin is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.