(S)-1-Boc-3-hydroxypiperidine

About (S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine is a metabolite or degradation product of Ibrutinib carrying the CAS registry number 143900-44-1. Its molecular formula is C10H19NO3 and its molecular weight is 201.26 g/mol. The IUPAC name is tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate. Alternative names: (S)-1-N-Boc-3-Hydroxy-piperidine and (S)-N-Boc-3-hydroxypiperidine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Ibrutinib, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (S)-1-Boc-3-hydroxypiperidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-1-Boc-3-hydroxypiperidine
Catalogue No.	VQ-031121
CAS Number	143900-44-1
IUPAC name	tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Molecular formula	C₁₀H₁₉NO₃
Molecular weight	201.26 g/mol
Exact mass	201.1365
Grade	Reference Standard
HSN code	38229090
InChIKey	UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES	CC(C)(C)OC(=O)N1CCC[C@@H](C1)O
PubChem CID	1514399

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	1 / 3
TPSA	49.8 Å²
Synonyms	(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, (S)-1-N-Boc-3-Hydroxy-piperidine, (S)-N-Boc-3-hydroxypiperidine, tert-butyl (S)-3-hydroxypiperidine-1-carboxylate, (S)-1-N-Boc-3-hydroxypiperidine, (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine, (S)-1-Boc-3-piperidinol, (S)-3-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester, (S)-3-hydroxy-N-Boc-piperidine, (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine, (S)-tert-butyl3-hydroxypiperidine-1-carboxylate, (S)-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-1-Boc-3-hydroxypiperidine?

The CAS Registry Number of (S)-1-Boc-3-hydroxypiperidine is 143900-44-1. It is also known as (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, (S)-1-N-Boc-3-Hydroxy-piperidine, (S)-N-Boc-3-hydroxypiperidine.

What is the molecular formula and molecular weight of (S)-1-Boc-3-hydroxypiperidine?

(S)-1-Boc-3-hydroxypiperidine has the molecular formula C10H19NO3 and a molecular weight of 201.26 g/mol. Its IUPAC name is tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate.

What is (S)-1-Boc-3-hydroxypiperidine used for?

(S)-1-Boc-3-hydroxypiperidine is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-1-Boc-3-hydroxypiperidine can I order?

We supply (S)-1-Boc-3-hydroxypiperidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-1-Boc-3-hydroxypiperidine?

Yes. Every lot of (S)-1-Boc-3-hydroxypiperidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-1-Boc-3-hydroxypiperidine be shipped internationally?

Yes. (S)-1-Boc-3-hydroxypiperidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.