Afatinib Impurity J

About Afatinib Impurity J

Afatinib Impurity J is an impurity of Afatinib carrying the CAS registry number 1456696-14-2. Formula C18H22N4O4, molecular weight 358.4 g/mol. The IUPAC name is (E)-4-(dimethylamino)-N-[4-oxo-7-[(3S)-oxolan-3-yl]oxy-3H-quinazolin-6-yl]but-2-enamide. Alternative names: Afatinib Oxoquinazoline Impurity and Afatinib Impurity 36.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Afatinib Impurity J in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Impurity J
Catalogue No.	VQ-021449
CAS Number	1456696-14-2
IUPAC name	(E)-4-(dimethylamino)-N-[4-oxo-7-[(3S)-oxolan-3-yl]oxy-3H-quinazolin-6-yl]but-2-enamide
Molecular formula	C₁₈H₂₂N₄O₄
Molecular weight	358.4 g/mol
Exact mass	358.1641
Grade	Reference Standard
HSN code	38229090
InChIKey	GSUSIQVMAQBROU-PCAWENJQSA-N
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=O)NC=N2)O[C@H]3CCOC3
PubChem CID	136295075

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	2 / 6
TPSA	92.3 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Impurity J?

The CAS Registry Number of Afatinib Impurity J is 1456696-14-2. It is also known as Afatinib Oxoquinazoline Impurity, Afatinib Impurity 36.

What is the molecular formula and molecular weight of Afatinib Impurity J?

Afatinib Impurity J has the molecular formula C18H22N4O4 and a molecular weight of 358.4 g/mol. Its IUPAC name is (E)-4-(dimethylamino)-N-[4-oxo-7-[(3S)-oxolan-3-yl]oxy-3H-quinazolin-6-yl]but-2-enamide.

What is Afatinib Impurity J used for?

Afatinib Impurity J is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Impurity J can I order?

We supply Afatinib Impurity J in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Impurity J?

Yes. Every lot of Afatinib Impurity J is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Impurity J be shipped internationally?

Yes. We export Afatinib Impurity J worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.