3-(Cyclopropylmethoxy)-4-(difluoromethoxy)ben… 151103-09-2

About 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is an impurity of Roflumilast carrying the CAS registry number 151103-09-2. With the molecular formula C12H12F2O3, it has a molar mass of 242.22 g/mol. Common synonyms include Roflumilast intermediate A and RofluMilast interMediate.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Roflumilast impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Specifications & identifiers

Chemical identifiers
Product name	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Catalogue No.	VQ-033634
CAS Number	151103-09-2
IUPAC name	3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Molecular formula	C₁₂H₁₂F₂O₃
Molecular weight	242.22 g/mol
Exact mass	242.0755
Grade	Reference Standard
HSN code	38229090
InChIKey	AHVVCELVGCPYGI-UHFFFAOYSA-N
SMILES	C1CC1COC2=C(C=CC(=C2)C=O)OC(F)F
PubChem CID	18973698

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	0 / 5
TPSA	35.5 Å²
Synonyms	4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde, Benzaldehyde, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-, Roflumilast intermediate A, RofluMilast interMediate, RofluMilast InterMediate I, 3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde, 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyd

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde?

The CAS Registry Number of 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is 151103-09-2. It is also known as 4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde, Benzaldehyde, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-, Roflumilast intermediate A.

What is the molecular formula and molecular weight of 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde?

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde has the molecular formula C12H12F2O3 and a molecular weight of 242.22 g/mol. Its IUPAC name is 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde.

What is 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde used for?

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde can I order?

We supply 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde?

Yes. Every lot of 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde be shipped internationally?

Yes. 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.