N-Nitroso Clozapine

Name: N-Nitroso Clozapine
Brand: Vaqora Chemicals
SKU: VQ-021196

About N-Nitroso Clozapine

N-Nitroso Clozapine (CAS 156632-03-0) is a nitrosamine impurity of Clozapine offered by Vaqora Chemicals. The compound has the formula C18H18ClN5O, corresponding to a molecular weight of 355.8 g/mol. Systematically, it is named 3-chloro-6-(4-methylpiperazin-1-yl)-11-nitrosobenzo[b][1,4]benzodiazepine. Alternative names: N-Nitroso Clozapine A and N-Nitroso Clozapine (mixture of isomers).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies N-Nitroso Clozapine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Clozapine
Catalogue No.	VQ-021196
CAS Number	156632-03-0
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)-11-nitrosobenzo[b][1,4]benzodiazepine
Molecular formula	C₁₈H₁₈ClN₅O
Molecular weight	355.8 g/mol
Exact mass	355.12
Grade	Reference Standard
HSN code	38229090
InChIKey	VUYZWBPSVAKAAT-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)N(C4=CC=CC=C42)N=O
PubChem CID	171390041

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	0 / 5
TPSA	51.5 Å²
Synonyms	N-Nitroso Clozapine A, N-Nitroso Clozapine (mixture of isomers), 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-5-nitroso-, 8-Chloro-11-(4-methyl-1-piperazinyl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Clozapine?

The CAS Registry Number of N-Nitroso Clozapine is 156632-03-0. It is also known as N-Nitroso Clozapine A, N-Nitroso Clozapine (mixture of isomers), 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-5-nitroso-.

What is the molecular formula and molecular weight of N-Nitroso Clozapine?

N-Nitroso Clozapine has the molecular formula C18H18ClN5O and a molecular weight of 355.8 g/mol. Its IUPAC name is 3-chloro-6-(4-methylpiperazin-1-yl)-11-nitrosobenzo[b][1,4]benzodiazepine.

What is N-Nitroso Clozapine used for?

N-Nitroso Clozapine is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Clozapine can I order?

We supply N-Nitroso Clozapine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Clozapine?

Yes. Every lot of N-Nitroso Clozapine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Clozapine be shipped internationally?

Yes. We export N-Nitroso Clozapine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.