7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin… 160129-45-3

Name: 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
Brand: Vaqora Chemicals
SKU: VQ-028453

About 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Listed under CAS 160129-45-3, 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is an impurity of Tolvaptan available from Vaqora Chemicals. The compound has the formula C10H10ClNO, corresponding to a molecular weight of 195.64 g/mol. Systematically, it is named 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one. It is also known as 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Tolvaptan impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Tolvaptan

View every impurity, metabolite and intermediate we list for Tolvaptan.

Tolvaptan impurities

Specifications & identifiers

Chemical identifiers
Product name	7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
Catalogue No.	VQ-028453
CAS Number	160129-45-3
IUPAC name	7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one
Molecular formula	C₁₀H₁₀ClNO
Molecular weight	195.64 g/mol
Exact mass	195.0451
Grade	Reference Standard
HSN code	38229090
InChIKey	AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES	C1CC(=O)C2=C(C=CC(=C2)Cl)NC1
PubChem CID	22903483

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	1 / 2
TPSA	29.1 Å²
Synonyms	7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one, 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one, 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine, 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-, 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one, AldrichCPR

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one?

The CAS Registry Number of 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is 160129-45-3. It is also known as 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one, 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one.

What is the molecular formula and molecular weight of 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one?

7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one has the molecular formula C10H10ClNO and a molecular weight of 195.64 g/mol. Its IUPAC name is 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one.

What is 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one used for?

7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is supplied as a characterised reference material related to Tolvaptan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one can I order?

We supply 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one?

Yes. Every lot of 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one be shipped internationally?

Yes. 7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.