![(4-Amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone chemical structure](/media/structures/QFCMTJUVQUTNSP-UHFFFAOYSA-N.svg)
(4-Amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone
- CAS
- 1859917-22-8
- Formula
- C18H17ClN2O
- MW
- 312.8 g/mol
VQ-042601
Impurity reference standards
Tolvaptan impurities & reference standards
Characterised Tolvaptan impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
45reference materials
1isotope-labelled
COAHPLC · NMR · MS on request
![(R)-N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide chemical structure](/media/structures/CJXNPZYKFICIJP-HSZRJFAPSA-N.svg)
(R)-N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide
- CAS
- 2376909-00-9
- Formula
- C25H23ClN2O3
- MW
- 434.9 g/mol
VQ-034343
![1-(4-Amino-2-methylbenzoyl)-7-chloro-2,3-dihydro-1H-benzo[b]azepin-5-yl 4-amino-2-methylbenzoate chemical structure](/media/structures/VBJOPOPXKGEFCP-UHFFFAOYSA-N.svg)
1-(4-Amino-2-methylbenzoyl)-7-chloro-2,3-dihydro-1H-benzo[b]azepin-5-yl 4-amino-2-methylbenzoate
- CAS
- 1580889-35-5
- Formula
- C26H24ClN3O3
- MW
- 461.9 g/mol
VQ-034345
![1-[4-(Benzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol chemical structure](/media/structures/LUMJRUXPFNZXRB-UHFFFAOYSA-N.svg)
1-[4-(Benzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
- CAS
- 1580889-33-3
- Formula
- C25H23ClN2O3
- MW
- 434.9 g/mol
VQ-023916
1,2,3,4-Tetrahydro-1-(4-Amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one
- CAS
- 137977-97-0
- Formula
- C18H17ClN2O2
- MW
- 328.8 g/mol
VQ-028452
![7-Chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3-dihydro-1H-benzo[b]azepin-5-yl 2-methyl-4-(2-methylbenzamido)benzoate chemical structure](/media/structures/IYRJYSVCAMDVEL-UHFFFAOYSA-N.svg)
7-Chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3-dihydro-1H-benzo[b]azepin-5-yl 2-methyl-4-(2-methylbenzamido)benzoate
- CAS
- 1580889-36-6
- Formula
- C42H36ClN3O5
- MW
- 698.2 g/mol
VQ-042607
![7-Chloro-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one chemical structure](/media/structures/UMJJRQXJGYESBD-UHFFFAOYSA-N.svg)
7-Chloro-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
- CAS
- 193686-76-9
- Formula
- C17H16ClNO3S
- MW
- 349.8 g/mol
VQ-034347
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
- CAS
- 137982-91-3
- Formula
- C18H15ClN2O4
- MW
- 358.8 g/mol
VQ-034339
![7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one chemical structure](/media/structures/AHESNFIUAHTYGS-UHFFFAOYSA-N.svg)
7-Chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
- CAS
- 160129-45-3
- Formula
- C10H10ClNO
- MW
- 195.64 g/mol
VQ-028453
![7-Chloro-2,3-dihydro-1H-benzo[b]azepine chemical structure](/media/structures/FSKMHCDLPSXAEH-UHFFFAOYSA-N.svg)
![7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol chemical structure](/media/structures/LRWLHLZOYPURQQ-UHFFFAOYSA-N.svg)
7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol
- CAS
- 1310357-40-4
- Formula
- C10H12ClNO
- MW
- 197.66 g/mol
VQ-023917
![7-Chloro-4-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine chemical structure](/media/structures/XNELQNRWMCDLRC-UHFFFAOYSA-N.svg)
7-Chloro-4-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine
- CAS
- 1863916-82-8
- Formula
- C11H14ClNO
- MW
- 211.69 g/mol
VQ-028454
![Ethyl 7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate chemical structure](/media/structures/JCSQLIDJOVIORL-UHFFFAOYSA-N.svg)
Ethyl 7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate
- CAS
- 1133419-00-7
- Formula
- C20H20ClNO5S
- MW
- 421.9 g/mol
VQ-028455
Methyl 5-chloro-2-((4-methylphenyl)sulfonamido)benzoate
- CAS
- 247237-38-3
- Formula
- C15H14ClNO4S
- MW
- 339.8 g/mol
VQ-032452
Methyl 5-chloro-2-((N-(4-ethoxy-4-oxobutyl)-4-methylphenyl)sulfonamido)benzoate
- CAS
- 247237-43-0
- Formula
- C21H24ClNO6S
- MW
- 453.9 g/mol
VQ-034346
![N-(4-(5-Hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide](/media/pack/n-4-5-hydroxy-2345-tetrahydro-1h-benzobazepine-1-carbonylphenyl-2-methylbenzamide.svg?v=3)
N-(4-(5-Hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide
- CAS
- 150681-19-9
- Formula
- C25H24N2O3
- MW
- 400.47 g/mol
VQ-042604
![N-(4-(5-Hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide chemical structure](/media/structures/YXURBXJRSQMPRO-UHFFFAOYSA-N.svg)
N-(4-(5-Hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
- CAS
- 1859917-54-6
- Formula
- C27H28N2O4
- MW
- 444.5 g/mol
VQ-042600
![N-(4-(7-Chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide chemical structure](/media/structures/JUIZVUYPMQYFHZ-UHFFFAOYSA-N.svg)
N-(4-(7-Chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
- CAS
- 176970-21-1
- Formula
- C26H23ClN2O2
- MW
- 430.9 g/mol
VQ-034342
![N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-3-methylbenzamide chemical structure](/media/structures/GWBNEPBGYSQILL-UHFFFAOYSA-N.svg)
N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-3-methylbenzamide
- CAS
- 1580889-27-5
- Formula
- C26H25ClN2O3
- MW
- 448.9 g/mol
VQ-042599
![N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide chemical structure](/media/structures/CJXNPZYKFICIJP-UHFFFAOYSA-N.svg)
N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide
- CAS
- 150683-27-5
- Formula
- C25H23ClN2O3
- MW
- 434.9 g/mol
VQ-028457
![N-(4-(7-Chloro-5-methoxy-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide chemical structure](/media/structures/UJIAUJZSJYOAGC-UHFFFAOYSA-N.svg)
N-(4-(7-Chloro-5-methoxy-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
- CAS
- 2468638-31-3
- Formula
- C27H25ClN2O3
- MW
- 460.9 g/mol
VQ-028459
![N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)benzamide chemical structure](/media/structures/PWBLFWOTMGULQA-UHFFFAOYSA-N.svg)
N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)benzamide
- CAS
- 1580889-32-2
- Formula
- C25H21ClN2O3
- MW
- 432.9 g/mol
VQ-042606
N-(4-Chloro-2-(1,4-dihydroxybutyl)phenyl)-2-methyl-4-(2-methylbenzamido)benzamide
- CAS
- 1587638-01-4
- Formula
- C26H27ClN2O4
- MW
- 467 g/mol
VQ-034348
N-(4-Chloro-2-(4-hydroxybutanoyl)phenyl)-2-methyl-4-(2-methylbenzamido)benzamide
- CAS
- 1587638-02-5
- Formula
- C26H25ClN2O4
- MW
- 464.9 g/mol
VQ-034349
FAQs — Tolvaptan impurities
Which Tolvaptan impurities do you supply?
We list 45 Tolvaptan-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Tolvaptan impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Tolvaptan impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Tolvaptan impurity standards
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