Clozapine-d4

Name: Clozapine-d4
Brand: Vaqora Chemicals
SKU: VQ-043394

About Clozapine-d4

Clozapine-d4 (CAS 204395-52-8) is a stable isotope labelled analogue related to Clozapine offered by Vaqora Chemicals. The compound has the formula C18H19ClN4, corresponding to a molecular weight of 330.8 g/mol. Systematically, it is named 3-chloro-6-(2,2,6,6-tetradeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine. Common synonyms include Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Clozapine and related analytes in bioanalytical, pharmacokinetic and impurity studies. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Clozapine-d4
Catalogue No.	VQ-043394
CAS Number	204395-52-8
IUPAC name	3-chloro-6-(2,2,6,6-tetradeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular formula	C₁₈H₁₉ClN₄
Molecular weight	330.8 g/mol
Exact mass	330.1549
Grade	Reference Standard
HSN code	38229090
InChIKey	QZUDBNBUXVUHMW-MKQHWYKPSA-N
SMILES	[2H]C1(CN(CC(N1C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)([2H])[2H])C)[2H]
PubChem CID	136951475

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 3
TPSA	30.9 Å²
Synonyms	5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d4)-, 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d4)-, Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4), 8-chloro-11-(4-methylpiperazin-1-yl-2,2,6,6-d4)-5H-dibenzo[b,e][1,4]diazepine, 8-Chloro-11-[4-methyl(2,2,6,6-~2~H_4_)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine, 3-chloro-6-(2,2,6,6-tetradeuterio-4-methyl-piperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clozapine-d4?

The CAS Registry Number of Clozapine-d4 is 204395-52-8. It is also known as 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d4)-, 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d4)-, Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4).

What is the molecular formula and molecular weight of Clozapine-d4?

Clozapine-d4 has the molecular formula C18H19ClN4 and a molecular weight of 330.8 g/mol. Its IUPAC name is 3-chloro-6-(2,2,6,6-tetradeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine.

What is Clozapine-d4 used for?

Clozapine-d4 is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clozapine-d4 can I order?

We supply Clozapine-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clozapine-d4?

Yes. Every lot of Clozapine-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clozapine-d4 be shipped internationally?

Yes. Clozapine-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.