Afatinib dimethyloxalamide impurity

About Afatinib dimethyloxalamide impurity

Afatinib dimethyloxalamide impurity is an impurity of Afatinib carrying the CAS registry number 2223677-66-3. With the molecular formula C22H21ClFN5O4, it has a molar mass of 473.9 g/mol. Its systematic (IUPAC) name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-N',N'-dimethyloxamide. It is also known as Afatinib Impurity CSEJXA or Afatinib Impurity 114.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

This Afatinib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Afatinib dimethyloxalamide impurity is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib dimethyloxalamide impurity
Catalogue No.	VQ-021450
CAS Number	2223677-66-3
IUPAC name	N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-N',N'-dimethyloxamide
Molecular formula	C₂₂H₂₁ClFN₅O₄
Molecular weight	473.9 g/mol
Exact mass	473.1266
Grade	Reference Standard
HSN code	38229090
InChIKey	TXTARPMHKVXFGC-ZDUSSCGKSA-N
SMILES	CN(C)C(=O)C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
PubChem CID	163197462

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	2 / 8
TPSA	106 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib dimethyloxalamide impurity?

The CAS Registry Number of Afatinib dimethyloxalamide impurity is 2223677-66-3. It is also known as Afatinib Impurity CSEJXA, Afatinib Impurity 114.

What is the molecular formula and molecular weight of Afatinib dimethyloxalamide impurity?

Afatinib dimethyloxalamide impurity has the molecular formula C22H21ClFN5O4 and a molecular weight of 473.9 g/mol. Its IUPAC name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-N',N'-dimethyloxamide.

What is Afatinib dimethyloxalamide impurity used for?

Afatinib dimethyloxalamide impurity is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib dimethyloxalamide impurity can I order?

We supply Afatinib dimethyloxalamide impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib dimethyloxalamide impurity?

Yes. Every lot of Afatinib dimethyloxalamide impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib dimethyloxalamide impurity be shipped internationally?

Yes. We export Afatinib dimethyloxalamide impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.