Timolol EP Impurity A

About Timolol EP Impurity A

Timolol EP Impurity A is a pharmacopeial impurity of Timolol carrying the CAS registry number 26839-76-9. With the molecular formula C13H24N4O3S, it has a molar mass of 316.42 g/mol. The IUPAC name is (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol. Alternative names: Timolol Maleate - Impurity A and (R)-timolol.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Timolol, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Timolol EP Impurity A in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Timolol

View every impurity, metabolite and intermediate we list for Timolol.

Timolol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Timolol EP Impurity A
Catalogue No.	VQ-028393
CAS Number	26839-76-9
IUPAC name	(2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Molecular formula	C₁₃H₂₄N₄O₃S
Molecular weight	316.42 g/mol
Exact mass	316.1569
Grade	Reference Standard
HSN code	38229090
InChIKey	BLJRIMJGRPQVNF-SNVBAGLBSA-N
SMILES	CC(C)(C)NC[C@H](COC1=NSN=C1N2CCOCC2)O
PubChem CID	168613

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	2 / 8
TPSA	108 Å²
Synonyms	Timolol Maleate - Impurity A, (R)-timolol, (+)-timolol, d-Timolol, (2R)-1-(tert-butylamino)-3-((4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol, Timolol, (+)-, (R)-(+)-Timolol, (2r)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol, Timolol Maleate Impurity 17, 1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol, (R)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol, 2-Propanol, 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements: P261, P271, P304 + P340, P319, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Timolol EP Impurity A?

The CAS Registry Number of Timolol EP Impurity A is 26839-76-9. It is also known as Timolol Maleate - Impurity A, (R)-timolol, (+)-timolol.

What is the molecular formula and molecular weight of Timolol EP Impurity A?

Timolol EP Impurity A has the molecular formula C13H24N4O3S and a molecular weight of 316.42 g/mol. Its IUPAC name is (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol.

What is Timolol EP Impurity A used for?

Timolol EP Impurity A is supplied as a characterised reference material related to Timolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Timolol EP Impurity A can I order?

We supply Timolol EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Timolol EP Impurity A?

Yes. Every lot of Timolol EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Timolol EP Impurity A be shipped internationally?

Yes. Timolol EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.