Ethyl 4-hydroxyquinoline-3-carboxylate

About Ethyl 4-hydroxyquinoline-3-carboxylate

Ethyl 4-hydroxyquinoline-3-carboxylate is a metabolite or degradation product of Ivacaftor carrying the CAS registry number 26892-90-0. Formula C12H11NO3, molecular weight 217.22 g/mol. Its systematic (IUPAC) name is ethyl 4-oxo-1H-quinoline-3-carboxylate. Alternative names: ethyl 4-oxohydroquinoline-3-carboxylate and 3-carboethoxy-1,4-dihydro-4-oxoquinoline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Ivacaftor, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Ethyl 4-hydroxyquinoline-3-carboxylate in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ivacaftor

View every impurity, metabolite and intermediate we list for Ivacaftor.

Ivacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Ethyl 4-hydroxyquinoline-3-carboxylate
Catalogue No.	VQ-050308
CAS Number	26892-90-0
IUPAC name	ethyl 4-oxo-1H-quinoline-3-carboxylate
Molecular formula	C₁₂H₁₁NO₃
Molecular weight	217.22 g/mol
Exact mass	217.0739
Grade	Reference Standard
HSN code	38229090
InChIKey	YBEOYBKKSWUSBR-UHFFFAOYSA-N
SMILES	CCOC(=O)C1=CNC2=CC=CC=C2C1=O
PubChem CID	220876

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	1 / 4
TPSA	55.4 Å²
Synonyms	4-Hydroxyquinoline-3-carboxylic acid ethyl ester, Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate, 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester, Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate, 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester, 4-Oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester, ethyl 1,4-dihydro-4-oxoquinoline-3-carboxylate, ethyl 4-oxohydroquinoline-3-carboxylate, 3-carboethoxy-1,4-dihydro-4-oxoquinoline, 1H-quinolin-4-one-3-carboxylic acid ethyl ester, 4-Hydroxy-quinoline-3-carboxylic acid ethyl ester

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements: P264 + P265, P280, P305 + P351 + P338, P337 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ethyl 4-hydroxyquinoline-3-carboxylate?

The CAS Registry Number of Ethyl 4-hydroxyquinoline-3-carboxylate is 26892-90-0. It is also known as 4-Hydroxyquinoline-3-carboxylic acid ethyl ester, Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate, 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester.

What is the molecular formula and molecular weight of Ethyl 4-hydroxyquinoline-3-carboxylate?

Ethyl 4-hydroxyquinoline-3-carboxylate has the molecular formula C12H11NO3 and a molecular weight of 217.22 g/mol. Its IUPAC name is ethyl 4-oxo-1H-quinoline-3-carboxylate.

What is Ethyl 4-hydroxyquinoline-3-carboxylate used for?

Ethyl 4-hydroxyquinoline-3-carboxylate is supplied as a characterised reference material related to Ivacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ethyl 4-hydroxyquinoline-3-carboxylate can I order?

We supply Ethyl 4-hydroxyquinoline-3-carboxylate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ethyl 4-hydroxyquinoline-3-carboxylate?

Yes. Every lot of Ethyl 4-hydroxyquinoline-3-carboxylate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ethyl 4-hydroxyquinoline-3-carboxylate be shipped internationally?

Yes. Ethyl 4-hydroxyquinoline-3-carboxylate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.