Ivacaftor D18

Name: Ivacaftor D18
Brand: Vaqora Chemicals
SKU: VQ-037793

About Ivacaftor D18

Vaqora Chemicals supplies Ivacaftor D18, a stable isotope labelled analogue related to Ivacaftor registered under CAS number 1413431-05-6. The compound has the formula C24H28N2O3, corresponding to a molecular weight of 392.5 g/mol. Its systematic (IUPAC) name is N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide. Common synonyms include Ivacaftor-d18 (d17 Major) and VX-770.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Ivacaftor D18 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Ivacaftor

View every impurity, metabolite and intermediate we list for Ivacaftor.

Ivacaftor impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Ivacaftor D18
Catalogue No.	VQ-037793
CAS Number	1413431-05-6
IUPAC name	N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide
Molecular formula	C₂₄H₂₈N₂O₃
Molecular weight	392.5 g/mol
Exact mass	392.21
Grade	Reference Standard
HSN code	38229090
InChIKey	PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
PubChem CID	16220172

Physical properties
Physical form	Solid
LogP (XLogP3)	5.6
H-bond donors / acceptors	3 / 4
TPSA	78.4 Å²
Synonyms	Ivacaftor-d18 (d17 Major), VX-770, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide, Elexacaftor, Tezacaftor, and Ivacaftor, Ivacaftor (VX-770), N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide, VX 770

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ivacaftor D18?

The CAS Registry Number of Ivacaftor D18 is 1413431-05-6. It is also known as Ivacaftor-d18 (d17 Major), VX-770, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide.

What is the molecular formula and molecular weight of Ivacaftor D18?

Ivacaftor D18 has the molecular formula C24H28N2O3 and a molecular weight of 392.5 g/mol. Its IUPAC name is N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide.

What is Ivacaftor D18 used for?

Ivacaftor D18 is supplied as a characterised reference material related to Ivacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ivacaftor D18 can I order?

We supply Ivacaftor D18 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ivacaftor D18?

Yes. Every lot of Ivacaftor D18 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ivacaftor D18 be shipped internationally?

Yes. Ivacaftor D18 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.