Ivacaftor-d9

Name: Ivacaftor-d9
Brand: Vaqora Chemicals
SKU: VQ-037794

About Ivacaftor-d9

Vaqora Chemicals supplies Ivacaftor-d9, a stable isotope labelled analogue related to Ivacaftor registered under CAS number 1413431-07-8. With the molecular formula C24H28N2O3, it has a molar mass of 401.5 g/mol. It is also known as Deutivacaftor or D9-ivacaftor.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Ivacaftor and related analytes in bioanalytical, pharmacokinetic and impurity studies. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Ivacaftor-d9 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Ivacaftor

View every impurity, metabolite and intermediate we list for Ivacaftor.

Ivacaftor impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Ivacaftor-d9
Catalogue No.	VQ-037794
CAS Number	1413431-07-8
IUPAC name	N-[2-tert-butyl-4-[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]-5-hydroxyphenyl]-4-oxo-1H-quinoline-3-carboxamide
Molecular formula	C₂₄H₂₈N₂O₃
Molecular weight	401.5 g/mol
Exact mass	401.2665
Grade	Reference Standard
HSN code	38229090
InChIKey	PURKAOJPTOLRMP-ASMGOKTBSA-N
SMILES	[2H]C([2H])([2H])C(C1=C(C=C(C(=C1)C(C)(C)C)NC(=O)C2=CNC3=CC=CC=C3C2=O)O)(C([2H])([2H])[2H])C([2H])([2H])[2H]
PubChem CID	71470491

Physical properties
Physical form	Solid
LogP (XLogP3)	5.6
H-bond donors / acceptors	3 / 4
TPSA	78.4 Å²
Synonyms	Deutivacaftor, D9-ivacaftor, VX-561, CTP-656, Ivacaftor (4-tertbutyl-d9) (Major), Ivacaftor (4-tertbutyl-d9), EX-A7897

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ivacaftor-d9?

The CAS Registry Number of Ivacaftor-d9 is 1413431-07-8. It is also known as Deutivacaftor, D9-ivacaftor, VX-561.

What is the molecular formula and molecular weight of Ivacaftor-d9?

Ivacaftor-d9 has the molecular formula C24H28N2O3 and a molecular weight of 401.5 g/mol. Its IUPAC name is N-[2-tert-butyl-4-[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]-5-hydroxyphenyl]-4-oxo-1H-quinoline-3-carboxamide.

What is Ivacaftor-d9 used for?

Ivacaftor-d9 is supplied as a characterised reference material related to Ivacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ivacaftor-d9 can I order?

We supply Ivacaftor-d9 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ivacaftor-d9?

Yes. Every lot of Ivacaftor-d9 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ivacaftor-d9 be shipped internationally?

Yes. Ivacaftor-d9 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.