N-Desmethyl Vandetanib

Name: N-Desmethyl Vandetanib
Brand: Vaqora Chemicals
SKU: VQ-028633

About N-Desmethyl Vandetanib

Listed under CAS 338992-12-4, N-Desmethyl Vandetanib is a metabolite or degradation product of Vandetanib available from Vaqora Chemicals. Its molecular formula is C21H22BrFN4O2 and its molecular weight is 461.3 g/mol. Systematically, it is named N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine. Common synonyms include N-Demethyl Vandetanib and N-Desmethyl-ZD6474.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Vandetanib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies N-Desmethyl Vandetanib in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Vandetanib

View every impurity, metabolite and intermediate we list for Vandetanib.

Vandetanib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Vandetanib
Catalogue No.	VQ-028633
CAS Number	338992-12-4
IUPAC name	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine
Molecular formula	C₂₁H₂₂BrFN₄O₂
Molecular weight	461.3 g/mol
Exact mass	460.091
Grade	Reference Standard
HSN code	38229090
InChIKey	HTCPERSEGREUFC-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCC4CCNCC4
PubChem CID	5329048

Physical properties
Physical form	Solid
LogP (XLogP3)	4.5
H-bond donors / acceptors	2 / 7
TPSA	68.3 Å²
Synonyms	N-Demethyl Vandetanib, N-Desmethyl-ZD6474, N-Desmethyl metabolite of vandetanib, 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-((piperidin-4-yl)methoxy)quinazoline, 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazolin-4-amine, 4-Anilinoquinazoline 22, 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazoline, N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-(4-piperidylmethoxy)quinazolin-4-amine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Vandetanib?

The CAS Registry Number of N-Desmethyl Vandetanib is 338992-12-4. It is also known as N-Demethyl Vandetanib, N-Desmethyl-ZD6474, N-Desmethyl metabolite of vandetanib.

What is the molecular formula and molecular weight of N-Desmethyl Vandetanib?

N-Desmethyl Vandetanib has the molecular formula C21H22BrFN4O2 and a molecular weight of 461.3 g/mol. Its IUPAC name is N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine.

What is N-Desmethyl Vandetanib used for?

N-Desmethyl Vandetanib is supplied as a characterised reference material related to Vandetanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Vandetanib can I order?

We supply N-Desmethyl Vandetanib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Vandetanib?

Yes. Every lot of N-Desmethyl Vandetanib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Vandetanib be shipped internationally?

Yes. We export N-Desmethyl Vandetanib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.