5-Bromo-2-hydroxypyrimidine

Name: 5-Bromo-2-hydroxypyrimidine
Brand: Vaqora Chemicals
SKU: VQ-039213

About 5-Bromo-2-hydroxypyrimidine

Listed under CAS 38353-06-9, 5-Bromo-2-hydroxypyrimidine is a metabolite or degradation product of Macitentan available from Vaqora Chemicals. With the molecular formula C4H3BrN2O, it has a molar mass of 174.98 g/mol. Systematically, it is named 5-bromo-1H-pyrimidin-2-one. It is also known as 5-Bromo-2-pyrimidinone or 2(1H)-Pyrimidinone, 5-bromo-.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Macitentan, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 5-Bromo-2-hydroxypyrimidine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	5-Bromo-2-hydroxypyrimidine
Catalogue No.	VQ-039213
CAS Number	38353-06-9
IUPAC name	5-bromo-1H-pyrimidin-2-one
Molecular formula	C₄H₃BrN₂O
Molecular weight	174.98 g/mol
Exact mass	173.9429
Grade	Reference Standard
HSN code	38229090
InChIKey	VTUDATOSQGYWML-UHFFFAOYSA-N
SMILES	C1=C(C=NC(=O)N1)Br
PubChem CID	101494

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	1 / 1
TPSA	41.5 Å²
Synonyms	5-Bromo-2-pyrimidinone, 2(1H)-Pyrimidinone, 5-bromo-, 5-Bromo-2(1H)-pyrimidinone, 5-bromopyrimidin-2-ol, 5-Bromopyrimidin-2(1H)-one, 5-Bromo-2-pyrimidinol, 2-Pyrimidinol, 5-bromo-, 5-Bromopyrimidin-2-one, 5-Bromo-pyrimidin-2-ol, 2-Hydroxy-5-bromopyrimidine, 5-bromo-2-pyrimidone, 5-bromopyrimid-2-one

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-Bromo-2-hydroxypyrimidine?

The CAS Registry Number of 5-Bromo-2-hydroxypyrimidine is 38353-06-9. It is also known as 5-Bromo-2-pyrimidinone, 2(1H)-Pyrimidinone, 5-bromo-, 5-Bromo-2(1H)-pyrimidinone.

What is the molecular formula and molecular weight of 5-Bromo-2-hydroxypyrimidine?

5-Bromo-2-hydroxypyrimidine has the molecular formula C4H3BrN2O and a molecular weight of 174.98 g/mol. Its IUPAC name is 5-bromo-1H-pyrimidin-2-one.

What is 5-Bromo-2-hydroxypyrimidine used for?

5-Bromo-2-hydroxypyrimidine is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-Bromo-2-hydroxypyrimidine can I order?

We supply 5-Bromo-2-hydroxypyrimidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-Bromo-2-hydroxypyrimidine?

Yes. Every lot of 5-Bromo-2-hydroxypyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-Bromo-2-hydroxypyrimidine be shipped internationally?

Yes. 5-Bromo-2-hydroxypyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.