Vandetanib

Name: Vandetanib
Brand: Vaqora Chemicals
SKU: VQ-028631

About Vandetanib

Listed under CAS 443913-73-3, Vandetanib is a high-purity reference standard of Vandetanib available from Vaqora Chemicals. Formula C22H24BrFN4O2, molecular weight 475.4 g/mol. Its systematic (IUPAC) name is N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine. Common synonyms include GNF-PF-2188 and ZD-64.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Vandetanib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Vandetanib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Vandetanib

View every impurity, metabolite and intermediate we list for Vandetanib.

Vandetanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Vandetanib
Catalogue No.	VQ-028631
CAS Number	443913-73-3
IUPAC name	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular formula	C₂₂H₂₄BrFN₄O₂
Molecular weight	475.4 g/mol
Exact mass	474.1067
Grade	Reference Standard
HSN code	38229090
InChIKey	UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES	CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
PubChem CID	3081361

Physical properties
Physical form	Solid
LogP (XLogP3)	4.9
H-bond donors / acceptors	1 / 7
TPSA	59.5 Å²
Synonyms	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine, GNF-PF-2188, ZD-64, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine, vandetanib (zd6474), 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline, AZD-6474, N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazolin-4-amine, 2ivu, CH 331

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P264, P270, P273, P280, P301 + P317, P318, P319, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Vandetanib?

The CAS Registry Number of Vandetanib is 443913-73-3. It is also known as N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine, GNF-PF-2188, ZD-64.

What is the molecular formula and molecular weight of Vandetanib?

Vandetanib has the molecular formula C22H24BrFN4O2 and a molecular weight of 475.4 g/mol. Its IUPAC name is N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine.

What is Vandetanib used for?

Vandetanib is supplied as a characterised reference material related to Vandetanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Vandetanib can I order?

We supply Vandetanib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Vandetanib?

Yes. Every lot of Vandetanib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Vandetanib be shipped internationally?

Yes. Vandetanib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.