Isotretinoin

About Isotretinoin

Isotretinoin is a high-purity reference standard of Isotretinoin carrying the CAS registry number 4759-48-2. With the molecular formula C20H28O2, it has a molar mass of 300.4 g/mol. Systematically, it is named (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid. It is also known as 13-cis-Retinoic acid or 13-cis-Retinoic acid).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Isotretinoin standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Isotretinoin

View every impurity, metabolite and intermediate we list for Isotretinoin.

Isotretinoin impurities

Specifications & identifiers

Chemical identifiers
Product name	Isotretinoin
Catalogue No.	VQ-007510
CAS Number	4759-48-2
IUPAC name	(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Molecular formula	C₂₀H₂₈O₂
Molecular weight	300.4 g/mol
Exact mass	300.2089
Grade	Reference Standard
HSN code	38229090
InChIKey	SHGAZHPCJJPHSC-XFYACQKRSA-N
SMILES	CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C
PubChem CID	5282379

Physical properties
Physical form	Solid
LogP (XLogP3)	6.3
H-bond donors / acceptors	1 / 2
TPSA	37.3 Å²
Synonyms	13-cis-Retinoic acid, 13-cis-Retinoic acid), (13Z)-Retinoic acid, 13-cis-Vitamin A acid, 13-cis-β-Retinoic acid, 13-RA, cis-Retinoic acid, Claravis, Roaccutan, Roaccutane, Accutane, Neovitamin A acid

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P261, P264, P264 + P265, P271, P273, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Isotretinoin?

The CAS Registry Number of Isotretinoin is 4759-48-2. It is also known as 13-cis-Retinoic acid, 13-cis-Retinoic acid), (13Z)-Retinoic acid.

What is the molecular formula and molecular weight of Isotretinoin?

Isotretinoin has the molecular formula C20H28O2 and a molecular weight of 300.4 g/mol. Its IUPAC name is (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid.

What is Isotretinoin used for?

Isotretinoin is supplied as a characterised reference material related to Isotretinoin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Isotretinoin can I order?

We supply Isotretinoin in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Isotretinoin?

Yes. Every lot of Isotretinoin is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Isotretinoin be shipped internationally?

Yes. Isotretinoin is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.