Levodopa-d3

About Levodopa-d3

Levodopa-d3 is a stable isotope labelled analogue related to Levodopa carrying the CAS registry number 53587-29-4. The compound has the formula C9H11NO4, corresponding to a molecular weight of 200.21 g/mol. Its systematic (IUPAC) name is (2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxyphenyl)propanoic acid. It is also known as 3-Hydroxy-L-(2,5,6-~2~H_3_)tyrosine or L-DOPA-2,5,6-d3.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Levodopa-d3 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Levodopa

View every impurity, metabolite and intermediate we list for Levodopa.

Levodopa impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Levodopa-d3
Catalogue No.	VQ-038002
CAS Number	53587-29-4
IUPAC name	(2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxyphenyl)propanoic acid
Molecular formula	C₉H₁₁NO₄
Molecular weight	200.21 g/mol
Exact mass	200.0876
Grade	Reference Standard
HSN code	38229090
InChIKey	WTDRDQBEARUVNC-UOCCHMHCSA-N
SMILES	[2H]C1=C(C(=C(C(=C1C[C@@H](C(=O)O)N)[2H])O)O)[2H]
PubChem CID	6914094

Physical properties
Physical form	Solid
LogP (XLogP3)	-2.7
H-bond donors / acceptors	4 / 5
TPSA	104 Å²
Synonyms	3-Hydroxy-L-(2,5,6-~2~H_3_)tyrosine, L-DOPA-2,5,6-d3, 3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine, L-DOPA-d3, L-Dopa-(phenyl-d3), TMIJ-0312, 5-Hydroxy-L-tyrosine-2,3,6-d3, (S)-2-Amino-3-(3,4-dihydroxyphenyl-2,5,6-d3)propanoic acid, (2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxy-phenyl)propanoic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Levodopa-d3?

The CAS Registry Number of Levodopa-d3 is 53587-29-4. It is also known as 3-Hydroxy-L-(2,5,6-~2~H_3_)tyrosine, L-DOPA-2,5,6-d3, 3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine.

What is the molecular formula and molecular weight of Levodopa-d3?

Levodopa-d3 has the molecular formula C9H11NO4 and a molecular weight of 200.21 g/mol. Its IUPAC name is (2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxyphenyl)propanoic acid.

What is Levodopa-d3 used for?

Levodopa-d3 is supplied as a characterised reference material related to Levodopa. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Levodopa-d3 can I order?

We supply Levodopa-d3 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Levodopa-d3?

Yes. Every lot of Levodopa-d3 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Levodopa-d3 be shipped internationally?

Yes. Levodopa-d3 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.