1-Hydroxy Midazolam

Name: 1-Hydroxy Midazolam
Brand: Vaqora Chemicals
SKU: VQ-044849

About 1-Hydroxy Midazolam

Listed under CAS 59468-90-5, 1-Hydroxy Midazolam is a metabolite or degradation product of Midazolam available from Vaqora Chemicals. With the molecular formula C18H13ClFN3O, it has a molar mass of 341.8 g/mol. Systematically, it is named [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol. Common synonyms include alpha-Hydroxymidazolam and 1-Hydroxymethylmidazolam.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Midazolam, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 1-Hydroxy Midazolam in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Midazolam

View every impurity, metabolite and intermediate we list for Midazolam.

Midazolam impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Hydroxy Midazolam
Catalogue No.	VQ-044849
CAS Number	59468-90-5
IUPAC name	[8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol
Molecular formula	C₁₈H₁₃ClFN₃O
Molecular weight	341.8 g/mol
Exact mass	341.0731
Grade	Reference Standard
HSN code	38229090
InChIKey	QHSMEGADRFZVNE-UHFFFAOYSA-N
SMILES	C1C2=CN=C(N2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4F)CO
PubChem CID	107917

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	1 / 4
TPSA	50.4 Å²
Synonyms	alpha-Hydroxymidazolam, 1-Hydroxymethylmidazolam, 1-OH-Mdz, 8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol, 8-Chloro-6-(2-fluorophenyl)-4H-imidazo(1,5-a)(1,4)benzodiazepine-1-methanol, 4H-Imidazo(1,5-a)(1,4)benzodiazepine-1-methanol, 8-chloro-6-(2-fluorophenyl)-, Controlled Substance (1 inverted exclamation marka-Hydroxymidazolam), (8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)methanol

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Hydroxy Midazolam?

The CAS Registry Number of 1-Hydroxy Midazolam is 59468-90-5. It is also known as alpha-Hydroxymidazolam, 1-Hydroxymethylmidazolam, 1-OH-Mdz.

What is the molecular formula and molecular weight of 1-Hydroxy Midazolam?

1-Hydroxy Midazolam has the molecular formula C18H13ClFN3O and a molecular weight of 341.8 g/mol. Its IUPAC name is [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol.

What is 1-Hydroxy Midazolam used for?

1-Hydroxy Midazolam is supplied as a characterised reference material related to Midazolam. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Hydroxy Midazolam can I order?

We supply 1-Hydroxy Midazolam in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Hydroxy Midazolam?

Yes. Every lot of 1-Hydroxy Midazolam is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Hydroxy Midazolam be shipped internationally?

Yes. We export 1-Hydroxy Midazolam worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.