Estradiol-d4

Name: Estradiol-d4
Brand: Vaqora Chemicals
SKU: VQ-037135

About Estradiol-d4

Listed under CAS 66789-03-5, Estradiol-d4 is a stable isotope labelled analogue related to Estradiol available from Vaqora Chemicals. The compound has the formula C18H24O2, corresponding to a molecular weight of 276.4 g/mol. It is also known as 17beta-ESTRADIOL-2,4,16,16-D4 or 17b-Estradiol-d4.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Estradiol and related analytes in bioanalytical, pharmacokinetic and impurity studies. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Estradiol

View every impurity, metabolite and intermediate we list for Estradiol.

Estradiol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Estradiol-d4
Catalogue No.	VQ-037135
CAS Number	66789-03-5
IUPAC name	(8R,9S,13S,14S,17S)-2,4,16,16-tetradeuterio-13-methyl-7,8,9,11,12,14,15,17-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
Molecular formula	C₁₈H₂₄O₂
Molecular weight	276.4 g/mol
Exact mass	276.2027
Grade	Reference Standard
HSN code	38229090
InChIKey	VOXZDWNPVJITMN-GKCQEISNSA-N
SMILES	[2H]C1=CC2=C(CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC([C@@H]4O)([2H])[2H])C)C(=C1O)[2H]
PubChem CID	87229045

Physical properties
Physical form	Solid
LogP (XLogP3)	4
H-bond donors / acceptors	2 / 2
TPSA	40.5 Å²
Synonyms	17beta-ESTRADIOL-2,4,16,16-D4, 17b-Estradiol-d4, 17beta-estradiol-d4, Estradiol-d4 (17-beta-Estradiol-d4), TMID-0055, (17beta)-Estra-1,3,5(10)-triene-2,4,16,16-d4-3,17-diol

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Estradiol-d4?

The CAS Registry Number of Estradiol-d4 is 66789-03-5. It is also known as 17beta-ESTRADIOL-2,4,16,16-D4, 17b-Estradiol-d4, 17beta-estradiol-d4.

What is the molecular formula and molecular weight of Estradiol-d4?

Estradiol-d4 has the molecular formula C18H24O2 and a molecular weight of 276.4 g/mol. Its IUPAC name is (8R,9S,13S,14S,17S)-2,4,16,16-tetradeuterio-13-methyl-7,8,9,11,12,14,15,17-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol.

What is Estradiol-d4 used for?

Estradiol-d4 is supplied as a characterised reference material related to Estradiol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Estradiol-d4 can I order?

We supply Estradiol-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Estradiol-d4?

Yes. Every lot of Estradiol-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Estradiol-d4 be shipped internationally?

Yes. We export Estradiol-d4 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.