Levothyroxine EP Impurity D

About Levothyroxine EP Impurity D

Levothyroxine EP Impurity D is a pharmacopeial impurity of Levothyroxine carrying the CAS registry number 67-30-1. Formula C14H8I4O4, molecular weight 747.83 g/mol. Systematically, it is named 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid. It is also known as Tetraiodothyroacetic Acid or 3,5,3',5'-Tetraiodo Thyroacetic Acid.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

This Levothyroxine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Levothyroxine

View every impurity, metabolite and intermediate we list for Levothyroxine.

Levothyroxine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Levothyroxine EP Impurity D
Catalogue No.	VQ-006471
CAS Number	67-30-1
IUPAC name	2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid
Molecular formula	C₁₄H₈I₄O₄
Molecular weight	747.83 g/mol
Exact mass	747.6601
Grade	Reference Standard
HSN code	38229090
InChIKey	PPJYSSNKSXAVDB-UHFFFAOYSA-N
SMILES	C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(=O)O
PubChem CID	65552

Physical properties
Physical form	Solid
LogP (XLogP3)	5.2
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	Tetraiodothyroacetic Acid, 3,5,3',5'-Tetraiodo Thyroacetic Acid, 3,3',5,5'-Tetraiodothyroacetic acid, 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid, [4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic Acid, Tetrac, T4-Acetic Acid (USP), T4-acetic acid, Thyroacetic acid, 3,3',5,5'-tetraiodo-, 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid, Acide 3,5,3',5'-tetraiodothyroacetique, Acetic acid, (4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Levothyroxine EP Impurity D?

The CAS Registry Number of Levothyroxine EP Impurity D is 67-30-1. It is also known as Tetraiodothyroacetic Acid, 3,5,3',5'-Tetraiodo Thyroacetic Acid, 3,3',5,5'-Tetraiodothyroacetic acid.

What is the molecular formula and molecular weight of Levothyroxine EP Impurity D?

Levothyroxine EP Impurity D has the molecular formula C14H8I4O4 and a molecular weight of 747.83 g/mol. Its IUPAC name is 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid.

What is Levothyroxine EP Impurity D used for?

Levothyroxine EP Impurity D is supplied as a characterised reference material related to Levothyroxine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Levothyroxine EP Impurity D can I order?

We supply Levothyroxine EP Impurity D in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Levothyroxine EP Impurity D?

Yes. Every lot of Levothyroxine EP Impurity D is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Levothyroxine EP Impurity D be shipped internationally?

Yes. Levothyroxine EP Impurity D is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.