Nitrosomethyl-N-butylamine

About Nitrosomethyl-N-butylamine

Nitrosomethyl-N-butylamine is a nitrosamine impurity of Valsartan carrying the CAS registry number 7068-83-9. Formula C5H12N2O, molecular weight 116.16 g/mol. Systematically, it is named N-butyl-N-methylnitrous amide. Common synonyms include N-Nitroso-N-methylbutylamine and N-Nitroso Methyl Butyl Amine.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Valsartan, method validation (AMV) and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Nitrosomethyl-N-butylamine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Valsartan

View every impurity, metabolite and intermediate we list for Valsartan.

Valsartan impurities

Specifications & identifiers

Chemical identifiers
Product name	Nitrosomethyl-N-butylamine
Catalogue No.	VQ-028627
CAS Number	7068-83-9
IUPAC name	N-butyl-N-methylnitrous amide
Molecular formula	C₅H₁₂N₂O
Molecular weight	116.16 g/mol
Exact mass	116.095
Grade	Reference Standard
HSN code	38229090
InChIKey	PKTSCJXWLVREKX-UHFFFAOYSA-N
SMILES	CCCCN(C)N=O
PubChem CID	23471

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	0 / 3
TPSA	32.7 Å²
Synonyms	N-Nitroso-N-methylbutylamine, N-Nitroso Methyl Butyl Amine, Methylbutylnitrosamine, Butylmethylnitrosamine, N-Methyl-N-nitrosobutylamine, Methyl-n-butylnitrosamine, Methylbutylnitrosoamine, N-Nitroso-n-butylmethylamine, N-Nitrosomethyl-N-butylamine, Butanamine, N-methyl-N-nitroso-, Butylamine, N-methyl-N-nitroso-, N-Butyl-N-methylnitrosamine

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
H350May cause cancer

Precautionary statements: P203, P260, P262, P264, P270, P271, P280, P284, P301 + P316, P302 + P352, P304 + P340, P316, P318, P320, P321, P330, P361 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nitrosomethyl-N-butylamine?

The CAS Registry Number of Nitrosomethyl-N-butylamine is 7068-83-9. It is also known as N-Nitroso-N-methylbutylamine, N-Nitroso Methyl Butyl Amine, Methylbutylnitrosamine.

What is the molecular formula and molecular weight of Nitrosomethyl-N-butylamine?

Nitrosomethyl-N-butylamine has the molecular formula C5H12N2O and a molecular weight of 116.16 g/mol. Its IUPAC name is N-butyl-N-methylnitrous amide.

What is Nitrosomethyl-N-butylamine used for?

Nitrosomethyl-N-butylamine is supplied as a characterised reference material related to Valsartan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nitrosomethyl-N-butylamine can I order?

We supply Nitrosomethyl-N-butylamine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nitrosomethyl-N-butylamine?

Yes. Every lot of Nitrosomethyl-N-butylamine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nitrosomethyl-N-butylamine be shipped internationally?

Yes. Nitrosomethyl-N-butylamine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.