O-Desmethyl Gefitinib

About O-Desmethyl Gefitinib

O-Desmethyl Gefitinib is a metabolite or degradation product of Gefitinib carrying the CAS registry number 847949-49-9. Formula C21H22ClFN4O3, molecular weight 432.9 g/mol. Its systematic (IUPAC) name is 4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)quinazolin-7-ol. It is also known as O-Demethyl-Gefitinib or O-DesmethylGefitinibmetabolite.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Gefitinib, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer O-Desmethyl Gefitinib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Gefitinib

View every impurity, metabolite and intermediate we list for Gefitinib.

Gefitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Desmethyl Gefitinib
Catalogue No.	VQ-025965
CAS Number	847949-49-9
IUPAC name	4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)quinazolin-7-ol
Molecular formula	C₂₁H₂₂ClFN₄O₃
Molecular weight	432.9 g/mol
Exact mass	432.1364
Grade	Reference Standard
HSN code	38229090
InChIKey	IFMMYZUUCFPEHR-UHFFFAOYSA-N
SMILES	C1COCCN1CCCOC2=C(C=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl)O
PubChem CID	135496227

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	2 / 8
TPSA	79.7 Å²
Synonyms	7-Quinazolinol,4-((3-chloro-4-fluorophenyl)amino)-6-(3-(4-morpholinyl)propoxy), 4-((3-Chloro-4-fluorophenyl)amino)-6-(3-morpholinopropoxy)quinazolin-7-ol, 7-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-, 4-[(3-Chloro-4-fluorophenyl)amino]-7-hydroxy-6-(3-morpholinopropoxy)quinazoline, O-Demethyl-Gefitinib, O-DesmethylGefitinibmetabolite, 7-Quinazolinol, 4-[(3-Chloro-4-Fluorophenyl)Amino]-6-[3-(4-Morpholinyl)Propoxy]-, 4-(3-chloro-4-fluoro-anilino)-6-(3-morpholinopropoxy)quinazolin-7-ol, 4-(3-Chloro-4-fluoroanilino)-6-[3-(morpholin-4-yl)propoxy]quinazolin-7(1H)-one

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Desmethyl Gefitinib?

The CAS Registry Number of O-Desmethyl Gefitinib is 847949-49-9. It is also known as 7-Quinazolinol,4-((3-chloro-4-fluorophenyl)amino)-6-(3-(4-morpholinyl)propoxy), 4-((3-Chloro-4-fluorophenyl)amino)-6-(3-morpholinopropoxy)quinazolin-7-ol, 7-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-.

What is the molecular formula and molecular weight of O-Desmethyl Gefitinib?

O-Desmethyl Gefitinib has the molecular formula C21H22ClFN4O3 and a molecular weight of 432.9 g/mol. Its IUPAC name is 4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)quinazolin-7-ol.

What is O-Desmethyl Gefitinib used for?

O-Desmethyl Gefitinib is supplied as a characterised reference material related to Gefitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Desmethyl Gefitinib can I order?

We supply O-Desmethyl Gefitinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Desmethyl Gefitinib?

Yes. Every lot of O-Desmethyl Gefitinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Desmethyl Gefitinib be shipped internationally?

Yes. We export O-Desmethyl Gefitinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.