Donepezil Hydrochloride Monohydrate

About Donepezil Hydrochloride Monohydrate

Donepezil Hydrochloride Monohydrate is a high-purity reference standard of Donepezil carrying the CAS registry number 884740-09-4. Formula C24H32ClNO4, molecular weight 434.0 g/mol. Systematically, it is named 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one. Hydrate. Hydrochloride. Common synonyms include Donepezil HCl monohydrate and Donepezil hydrochloride monohydrate CRS.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Donepezil, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Specifications & identifiers

Chemical identifiers
Product name	Donepezil Hydrochloride Monohydrate
Catalogue No.	VQ-007434
CAS Number	884740-09-4
Other CAS	120014-06-4, 120011-70-3
IUPAC name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrate;hydrochloride
Molecular formula	C₂₄H₃₂ClNO₄
Molecular weight	434 g/mol
Exact mass	433.202
Grade	Reference Standard
HSN code	38229090
InChIKey	HLJIZAKUNCTCQX-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.O.Cl
PubChem CID	11697764

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 5
TPSA	39.8 Å²

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Environmental hazard

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P264, P264 + P265, P270, P273, P280, P301 + P316, P305 + P351 + P338, P321, P330, P337 + P317, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Donepezil Hydrochloride Monohydrate?

The CAS Registry Number of Donepezil Hydrochloride Monohydrate is 884740-09-4. It is also known as (±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone Hydrochloride Monohydrate, Donepezil HCl monohydrate, Donepezil hydrochloride monohydrate CRS.

What is the molecular formula and molecular weight of Donepezil Hydrochloride Monohydrate?

Donepezil Hydrochloride Monohydrate has the molecular formula C24H32ClNO4 and a molecular weight of 434 g/mol.

What is Donepezil Hydrochloride Monohydrate used for?

Donepezil Hydrochloride Monohydrate is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Donepezil Hydrochloride Monohydrate can I order?

We supply Donepezil Hydrochloride Monohydrate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Donepezil Hydrochloride Monohydrate?

Yes. Every lot of Donepezil Hydrochloride Monohydrate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Donepezil Hydrochloride Monohydrate be shipped internationally?

Yes. Donepezil Hydrochloride Monohydrate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.