Neratinib Acetyl Impurity

About Neratinib Acetyl Impurity

Neratinib Acetyl Impurity is an impurity of Neratinib carrying the CAS registry number 915941-95-6 at a purity of 96%. The compound has the formula C26H22ClN5O3, corresponding to a molecular weight of 487.9 g/mol. Systematically, it is named N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]acetamide. Common synonyms include Neratinib Impurity N2 and C26H22ClN5O3.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Neratinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Neratinib

View every impurity, metabolite and intermediate we list for Neratinib.

Neratinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Neratinib Acetyl Impurity
Catalogue No.	VQ-005347
CAS Number	915941-95-6
IUPAC name	N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]acetamide
Molecular formula	C₂₆H₂₂ClN₅O₃
Molecular weight	487.9 g/mol
Exact mass	487.1411
Grade	Reference Standard
Purity / assay	96%
HSN code	38229090
InChIKey	YUNSMEPCTRVPTN-UHFFFAOYSA-N
SMILES	CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C
PubChem CID	25267994

Physical properties
Physical form	Solid
LogP (XLogP3)	4.6
H-bond donors / acceptors	2 / 7
TPSA	109 Å²
Synonyms	4-[3-Chloro-4-[(2-pyridyl)methoxy]anilino]-3-cyano-7-ethoxy-6-(N-acetylamino)quinoline, 4-(3-chloro-4-((2-pyridyl)methoxy)anilino)-3-cyano-7-ethoxy-6-(N-acetyl amino)quinoline, 4-[3-chloro-4-[(2-pyridyl)methoxy]anilino]-3-cyano-7-ethoxy-6-(N-acetyl amino)quinoline, 4-(3-Chloro-4-((2-pyridyl)methoxy)anilino)-3-cyano-7-ethoxy-6-(N-acetylamino)quinoline, Neratinib Impurity N2, C26H22ClN5O3, US10774068, Example 85, N-[4-[3-chloro-4-(2-pyridylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolyl]acetamide

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P264, P270, P273, P301 + P317, P330, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Neratinib Acetyl Impurity?

The CAS Registry Number of Neratinib Acetyl Impurity is 915941-95-6. It is also known as 4-[3-Chloro-4-[(2-pyridyl)methoxy]anilino]-3-cyano-7-ethoxy-6-(N-acetylamino)quinoline, 4-(3-chloro-4-((2-pyridyl)methoxy)anilino)-3-cyano-7-ethoxy-6-(N-acetyl amino)quinoline, 4-[3-chloro-4-[(2-pyridyl)methoxy]anilino]-3-cyano-7-ethoxy-6-(N-acetyl amino)quinoline.

What is the molecular formula and molecular weight of Neratinib Acetyl Impurity?

Neratinib Acetyl Impurity has the molecular formula C26H22ClN5O3 and a molecular weight of 487.9 g/mol. Its IUPAC name is N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]acetamide.

What is Neratinib Acetyl Impurity used for?

Neratinib Acetyl Impurity is supplied as a characterised reference material related to Neratinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Neratinib Acetyl Impurity can I order?

We supply Neratinib Acetyl Impurity in Reference Standard (96%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Neratinib Acetyl Impurity?

Yes. Every lot of Neratinib Acetyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Neratinib Acetyl Impurity be shipped internationally?

Yes. Neratinib Acetyl Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.