1,3-Benzodioxole-5-glycolic Acid

Name: 1,3-Benzodioxole-5-glycolic Acid
Brand: Vaqora Chemicals
SKU: VQ-027522

About 1,3-Benzodioxole-5-glycolic Acid

1,3-Benzodioxole-5-glycolic Acid (CAS 27738-46-1) is an impurity of Tadalafil offered by Vaqora Chemicals. Formula C9H8O5, molecular weight 196.16 g/mol. Systematically, it is named 2-(1,3-benzodioxol-5-yl)-2-hydroxyacetic acid. Common synonyms include 3,4-Methylenedioxymandelic acid and alpha-Hydroxy-1,3-benzodioxole-5-acetic acid.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Tadalafil to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Tadalafil

View every impurity, metabolite and intermediate we list for Tadalafil.

Tadalafil impurities

Specifications & identifiers

Chemical identifiers
Product name	1,3-Benzodioxole-5-glycolic Acid
Catalogue No.	VQ-027522
CAS Number	27738-46-1
IUPAC name	2-(1,3-benzodioxol-5-yl)-2-hydroxyacetic acid
Molecular formula	C₉H₈O₅
Molecular weight	196.16 g/mol
Exact mass	196.0372
Grade	Reference Standard
HSN code	38229090
InChIKey	CLUJFRCEPFNVHW-UHFFFAOYSA-N
SMILES	C1OC2=C(O1)C=C(C=C2)C(C(=O)O)O
PubChem CID	119618

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	2 / 5
TPSA	76 Å²
Synonyms	3,4-Methylenedioxymandelic acid, alpha-Hydroxy-1,3-benzodioxole-5-acetic acid, 3',4'-Methylenedioxymandelic acid, 3,4-(Methylenedioxy)mandelic acid, 2-(Benzo[d][1,3]dioxol-5-yl)-2-hydroxyacetic acid, 2-(1,3-benzodioxol-5-yl)-2-hydroxy-acetic acid, 1,3-Benzodioxole-5-acetic acid, .alpha.-hydroxy-, 2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetic acid, 1,3-Benzodioxol-5-yl(hydroxy)acetic acid, 1,3-Benzodioxole-5-acetic acid, alpha-hydroxy-, 2-(2H-benzo[d]1,3-dioxolen-5-yl)-2-hydroxyacetic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1,3-Benzodioxole-5-glycolic Acid?

The CAS Registry Number of 1,3-Benzodioxole-5-glycolic Acid is 27738-46-1. It is also known as 3,4-Methylenedioxymandelic acid, alpha-Hydroxy-1,3-benzodioxole-5-acetic acid, 3',4'-Methylenedioxymandelic acid.

What is the molecular formula and molecular weight of 1,3-Benzodioxole-5-glycolic Acid?

1,3-Benzodioxole-5-glycolic Acid has the molecular formula C9H8O5 and a molecular weight of 196.16 g/mol. Its IUPAC name is 2-(1,3-benzodioxol-5-yl)-2-hydroxyacetic acid.

What is 1,3-Benzodioxole-5-glycolic Acid used for?

1,3-Benzodioxole-5-glycolic Acid is supplied as a characterised reference material related to Tadalafil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1,3-Benzodioxole-5-glycolic Acid can I order?

We supply 1,3-Benzodioxole-5-glycolic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1,3-Benzodioxole-5-glycolic Acid?

Yes. Every lot of 1,3-Benzodioxole-5-glycolic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1,3-Benzodioxole-5-glycolic Acid be shipped internationally?

Yes. 1,3-Benzodioxole-5-glycolic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.