1',4-Dihydroxy Midazolam

Name: 1',4-Dihydroxy Midazolam
Brand: Vaqora Chemicals
SKU: VQ-035500

About 1',4-Dihydroxy Midazolam

1',4-Dihydroxy Midazolam is an impurity of Midazolam carrying the CAS registry number 64740-68-7. The compound has the formula C18H13ClFN3O2, corresponding to a molecular weight of 357.8 g/mol. Its systematic (IUPAC) name is 8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol. It is also known as alpha,4-dihydroxymidazolam.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Midazolam to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 1',4-Dihydroxy Midazolam is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Midazolam

View every impurity, metabolite and intermediate we list for Midazolam.

Midazolam impurities

Specifications & identifiers

Chemical identifiers
Product name	1',4-Dihydroxy Midazolam
Catalogue No.	VQ-035500
CAS Number	64740-68-7
IUPAC name	8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
Molecular formula	C₁₈H₁₃ClFN₃O₂
Molecular weight	357.8 g/mol
Exact mass	357.068
Grade	Reference Standard
HSN code	38229090
InChIKey	OJDUJEPGFILARE-UHFFFAOYSA-N
SMILES	C1=CC=C(C(=C1)C2=NC(C3=CN=C(N3C4=C2C=C(C=C4)Cl)CO)O)F
PubChem CID	10316307

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	2 / 5
TPSA	70.6 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1',4-Dihydroxy Midazolam?

The CAS Registry Number of 1',4-Dihydroxy Midazolam is 64740-68-7. It is also known as 8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol, alpha,4-dihydroxymidazolam.

What is the molecular formula and molecular weight of 1',4-Dihydroxy Midazolam?

1',4-Dihydroxy Midazolam has the molecular formula C18H13ClFN3O2 and a molecular weight of 357.8 g/mol. Its IUPAC name is 8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol.

What is 1',4-Dihydroxy Midazolam used for?

1',4-Dihydroxy Midazolam is supplied as a characterised reference material related to Midazolam. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1',4-Dihydroxy Midazolam can I order?

We supply 1',4-Dihydroxy Midazolam in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1',4-Dihydroxy Midazolam?

Yes. Every lot of 1',4-Dihydroxy Midazolam is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1',4-Dihydroxy Midazolam be shipped internationally?

Yes. We export 1',4-Dihydroxy Midazolam worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.