2-chloro-N-methyl-N-(4-nitrophenyl)acetamide

Name: 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
Brand: Vaqora Chemicals
SKU: VQ-012947

About 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide

Listed under CAS 2653-16-9, 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide is a process intermediate or related compound of Nintedanib available from Vaqora Chemicals. With the molecular formula C9H9ClN2O3, it has a molar mass of 228.63 g/mol. Alternative names: α-Chloro-N-methyl-p-nitroacetanilide and 2-Chloro-N-methyl-4'-nitro-acetanilide.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 6 hazard statements. Review the Safety Data Sheet before use.

It is a process intermediate or related compound in the synthesis of Nintedanib, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
Catalogue No.	VQ-012947
CAS Number	2653-16-9
IUPAC name	2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
Molecular formula	C₉H₉ClN₂O₃
Molecular weight	228.63 g/mol
Exact mass	228.0302
Grade	Reference Standard
HSN code	2933
InChIKey	JAWLWNKATJAODJ-UHFFFAOYSA-N
SMILES	CN(C1=CC=C(C=C1)[N+](=O)[O-])C(=O)CCl
PubChem CID	11436129

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	0 / 3
TPSA	66.1 Å²
Synonyms	α-Chloro-N-methyl-p-nitroacetanilide, 2-Chloro-N-methyl-4'-nitro-acetanilide, 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide, Acetamide, 2-chloro-N-methyl-N-(4-nitrophenyl)-, Nintedanib-004, Nintedanib intermediate, 2-Chloro-N-methyl-4'-nitroacetanilide, alpha-Chloro-N-methyl-p-nitroacetanilide, Acetanilide, 2-chloro-N-methyl-4'-nitro-, 2-chloro-N-methyl-N-(4-nitrophenyl) acetamide

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide?

The CAS Registry Number of 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide is 2653-16-9. It is also known as α-Chloro-N-methyl-p-nitroacetanilide, 2-Chloro-N-methyl-4'-nitro-acetanilide, 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide.

What is the molecular formula and molecular weight of 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide?

2-chloro-N-methyl-N-(4-nitrophenyl)acetamide has the molecular formula C9H9ClN2O3 and a molecular weight of 228.63 g/mol. Its IUPAC name is 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide.

What is 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide used for?

2-chloro-N-methyl-N-(4-nitrophenyl)acetamide is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide can I order?

We supply 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide?

Yes. Every lot of 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide be shipped internationally?

Yes. 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.