2,4,5-Trifluorophenylacetonitrile

Name: 2,4,5-Trifluorophenylacetonitrile
Brand: Vaqora Chemicals
SKU: VQ-032590

About 2,4,5-Trifluorophenylacetonitrile

Listed under CAS 220141-74-2, 2,4,5-Trifluorophenylacetonitrile is an impurity of Sitagliptin available from Vaqora Chemicals. The compound has the formula C8H4F3N, corresponding to a molecular weight of 171.12 g/mol. The IUPAC name is 2-(2,4,5-trifluorophenyl)acetonitrile. It is also known as 2,4,5-Trifluorobenzyl Cyanide or 2-(2,4,5-trifluorophenyl)ethanenitrile.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 9 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Sitagliptin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2,4,5-Trifluorophenylacetonitrile is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	2,4,5-Trifluorophenylacetonitrile
Catalogue No.	VQ-032590
CAS Number	220141-74-2
IUPAC name	2-(2,4,5-trifluorophenyl)acetonitrile
Molecular formula	C₈H₄F₃N
Molecular weight	171.12 g/mol
Exact mass	171.0296
Grade	Reference Standard
HSN code	38229090
InChIKey	JTYBTJVFXUKNKW-UHFFFAOYSA-N
SMILES	C1=C(C(=CC(=C1F)F)F)CC#N
PubChem CID	2777957

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	0 / 4
TPSA	23.8 Å²

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H330Fatal if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P260, P261, P262, P264, P264 + P265, P270, P271, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P317, P319, P320, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2,4,5-Trifluorophenylacetonitrile?

The CAS Registry Number of 2,4,5-Trifluorophenylacetonitrile is 220141-74-2. It is also known as 2,4,5-Trifluorobenzyl Cyanide, 2-(2,4,5-trifluorophenyl)ethanenitrile, 2,4,5-trifluorobenzylcyanide.

What is the molecular formula and molecular weight of 2,4,5-Trifluorophenylacetonitrile?

2,4,5-Trifluorophenylacetonitrile has the molecular formula C8H4F3N and a molecular weight of 171.12 g/mol. Its IUPAC name is 2-(2,4,5-trifluorophenyl)acetonitrile.

What is 2,4,5-Trifluorophenylacetonitrile used for?

2,4,5-Trifluorophenylacetonitrile is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2,4,5-Trifluorophenylacetonitrile can I order?

We supply 2,4,5-Trifluorophenylacetonitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2,4,5-Trifluorophenylacetonitrile?

Yes. Every lot of 2,4,5-Trifluorophenylacetonitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2,4,5-Trifluorophenylacetonitrile be shipped internationally?

Yes. 2,4,5-Trifluorophenylacetonitrile is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.