4a-Hydroxy-5-methyltetrahydrofolate

Name: 4a-Hydroxy-5-methyltetrahydrofolate
Brand: Vaqora Chemicals
SKU: VQ-025898

About 4a-Hydroxy-5-methyltetrahydrofolate

Listed under CAS 33157-07-2, 4a-Hydroxy-5-methyltetrahydrofolate is a metabolite or degradation product of Folinic Acid available from Vaqora Chemicals. With the molecular formula C20H25N7O7, it has a molar mass of 475.5 g/mol. Common synonyms include 4a-Hydroxy-5-Methyltetrahydrofolic Acid and 4a-hydroxy-n5-methyltetrahydrofolic acid.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Folinic Acid, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4a-Hydroxy-5-methyltetrahydrofolate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Folinic Acid

View every impurity, metabolite and intermediate we list for Folinic Acid.

Folinic Acid impurities

Specifications & identifiers

Chemical identifiers
Product name	4a-Hydroxy-5-methyltetrahydrofolate
Catalogue No.	VQ-025898
CAS Number	33157-07-2
IUPAC name	(2S)-2-[[4-[(2-amino-4a-hydroxy-5-methyl-4-oxo-6,7-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₅N₇O₇
Molecular weight	475.5 g/mol
Exact mass	475.1815
Grade	Reference Standard
HSN code	38229090
InChIKey	GJGYABXPRIKIEP-BTTAGBNVSA-N
SMILES	CN1C(CN=C2C1(C(=O)NC(=N2)N)O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	135618559

Physical properties
Physical form	Solid
LogP (XLogP3)	-4.2
H-bond donors / acceptors	7 / 10
TPSA	219 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4a-Hydroxy-5-methyltetrahydrofolate?

The CAS Registry Number of 4a-Hydroxy-5-methyltetrahydrofolate is 33157-07-2. It is also known as 4a-Hydroxy-5-Methyltetrahydrofolic Acid, 4a-hydroxy-n5-methyltetrahydrofolic acid, 4-alpha-hydroxy-5-methyltetrahydrofolic acid.

What is the molecular formula and molecular weight of 4a-Hydroxy-5-methyltetrahydrofolate?

4a-Hydroxy-5-methyltetrahydrofolate has the molecular formula C20H25N7O7 and a molecular weight of 475.5 g/mol. Its IUPAC name is (2S)-2-[[4-[(2-amino-4a-hydroxy-5-methyl-4-oxo-6,7-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid.

What is 4a-Hydroxy-5-methyltetrahydrofolate used for?

4a-Hydroxy-5-methyltetrahydrofolate is supplied as a characterised reference material related to Folinic Acid. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4a-Hydroxy-5-methyltetrahydrofolate can I order?

We supply 4a-Hydroxy-5-methyltetrahydrofolate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4a-Hydroxy-5-methyltetrahydrofolate?

Yes. Every lot of 4a-Hydroxy-5-methyltetrahydrofolate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4a-Hydroxy-5-methyltetrahydrofolate be shipped internationally?

Yes. We export 4a-Hydroxy-5-methyltetrahydrofolate worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.