N-Nitroso-leucovorin-2

Name: N-Nitroso-leucovorin-2
Brand: Vaqora Chemicals
SKU: VQ-025901

About N-Nitroso-leucovorin-2

Vaqora Chemicals supplies N-Nitroso-leucovorin-2, a nitrosamine impurity of Folinic Acid registered under CAS number 77314-00-2. With the molecular formula C20H22N8O8, it has a molar mass of 502.4 g/mol.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Folinic Acid, method validation (AMV) and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Folinic Acid

View every impurity, metabolite and intermediate we list for Folinic Acid.

Folinic Acid impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso-leucovorin-2
Catalogue No.	VQ-025901
CAS Number	77314-00-2
IUPAC name	(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methyl-nitrosoamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₈
Molecular weight	502.4 g/mol
Exact mass	502.1561
Grade	Reference Standard
HSN code	38229090
InChIKey	WSONKBPBZUZVOA-ABLWVSNPSA-N
SMILES	C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CN(C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N=O
PubChem CID	171390121

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.4
H-bond donors / acceptors	6 / 12
TPSA	236 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso-leucovorin-2?

The CAS Registry Number of N-Nitroso-leucovorin-2 is 77314-00-2.

What is the molecular formula and molecular weight of N-Nitroso-leucovorin-2?

N-Nitroso-leucovorin-2 has the molecular formula C20H22N8O8 and a molecular weight of 502.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methyl-nitrosoamino]benzoyl]amino]pentanedioic acid.

What is N-Nitroso-leucovorin-2 used for?

N-Nitroso-leucovorin-2 is supplied as a characterised reference material related to Folinic Acid. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso-leucovorin-2 can I order?

We supply N-Nitroso-leucovorin-2 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso-leucovorin-2?

Yes. Every lot of N-Nitroso-leucovorin-2 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso-leucovorin-2 be shipped internationally?

Yes. We export N-Nitroso-leucovorin-2 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.