6-Amino-4-((3-chloro-4-fluorophenyl)amino)qui… 1449430-53-8

Name: 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol
Brand: Vaqora Chemicals
SKU: VQ-047347

About 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol

Vaqora Chemicals supplies 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol, an impurity of Afatinib registered under CAS number 1449430-53-8. Formula C14H10ClFN4O, molecular weight 304.7 g/mol. Systematically, it is named 6-amino-4-(3-chloro-4-fluoroanilino)quinazolin-7-ol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Afatinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. A Safety Data Sheet (SDS) and technical specifications are available on request.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol
Catalogue No.	VQ-047347
CAS Number	1449430-53-8
IUPAC name	6-amino-4-(3-chloro-4-fluoroanilino)quinazolin-7-ol
Molecular formula	C₁₄H₁₀ClFN₄O
Molecular weight	304.7 g/mol
Exact mass	304.0527
Grade	Reference Standard
HSN code	38229090
InChIKey	YEFNIUDZICAGOU-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1NC2=NC=NC3=CC(=C(C=C32)N)O)Cl)F
PubChem CID	137100307

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	3 / 6
TPSA	84.1 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol?

The CAS Registry Number of 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol is 1449430-53-8. It is also known as 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-quinazolinol.

What is the molecular formula and molecular weight of 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol?

6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol has the molecular formula C14H10ClFN4O and a molecular weight of 304.7 g/mol. Its IUPAC name is 6-amino-4-(3-chloro-4-fluoroanilino)quinazolin-7-ol.

What is 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol used for?

6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol can I order?

We supply 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol?

Yes. Every lot of 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol be shipped internationally?

Yes. We export 6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.