7-Fluoro-6-nitro-4-hydroxyquinazoline

Name: 7-Fluoro-6-nitro-4-hydroxyquinazoline
Brand: Vaqora Chemicals
SKU: VQ-024155

About 7-Fluoro-6-nitro-4-hydroxyquinazoline

7-Fluoro-6-nitro-4-hydroxyquinazoline (CAS 162012-69-3) is an impurity of Afatinib offered by Vaqora Chemicals. With the molecular formula C8H4FN3O3, it has a molar mass of 209.13 g/mol. Systematically, it is named 7-fluoro-6-nitro-3H-quinazolin-4-one. Alternative names: 7-fluoro-6-nitroquinazolin-4(1H)-one and 7-Fluoro-6-nitroquinazolin-4(3H)-one.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 7-Fluoro-6-nitro-4-hydroxyquinazoline is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	7-Fluoro-6-nitro-4-hydroxyquinazoline
Catalogue No.	VQ-024155
CAS Number	162012-69-3
IUPAC name	7-fluoro-6-nitro-3H-quinazolin-4-one
Molecular formula	C₈H₄FN₃O₃
Molecular weight	209.13 g/mol
Exact mass	209.0237
Grade	Reference Standard
HSN code	38229090
InChIKey	VTUAEMSZEIGQRM-UHFFFAOYSA-N
SMILES	C1=C2C(=CC(=C1[N+](=O)[O-])F)N=CNC2=O
PubChem CID	135398507

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	1 / 5
TPSA	87.3 Å²
Synonyms	7-fluoro-6-nitroquinazolin-4(1H)-one, 7-Fluoro-6-nitroquinazolin-4(3H)-one, 7-fluoro-6-nitro-1H-quinazolin-4-one, 7-fluoro-6-nitro-3,4-dihydroquinazolin-4-one, 7-fluoro-6-nitroquinazolin-4-ol, 7-fluoro-4-hydroxy-6-nitroquinazoline, 4(3H)-Quinazolinone, 7-fluoro-6-nitro-, CS-B0788, 7-fluoro-6-nitroquinazoline-4(3H)-one, 7-fluoro-6-nitro-3-hydroquinazolin-4-one, 7-fluoro-6-nitro-1,4-dihydroquinazolin-4-one, 1-Benzyl-2,5-bis(chloromethyl)piperidine hydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 7-Fluoro-6-nitro-4-hydroxyquinazoline?

The CAS Registry Number of 7-Fluoro-6-nitro-4-hydroxyquinazoline is 162012-69-3. It is also known as 7-fluoro-6-nitroquinazolin-4(1H)-one, 7-Fluoro-6-nitroquinazolin-4(3H)-one, 7-fluoro-6-nitro-1H-quinazolin-4-one.

What is the molecular formula and molecular weight of 7-Fluoro-6-nitro-4-hydroxyquinazoline?

7-Fluoro-6-nitro-4-hydroxyquinazoline has the molecular formula C8H4FN3O3 and a molecular weight of 209.13 g/mol. Its IUPAC name is 7-fluoro-6-nitro-3H-quinazolin-4-one.

What is 7-Fluoro-6-nitro-4-hydroxyquinazoline used for?

7-Fluoro-6-nitro-4-hydroxyquinazoline is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 7-Fluoro-6-nitro-4-hydroxyquinazoline can I order?

We supply 7-Fluoro-6-nitro-4-hydroxyquinazoline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 7-Fluoro-6-nitro-4-hydroxyquinazoline?

Yes. Every lot of 7-Fluoro-6-nitro-4-hydroxyquinazoline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 7-Fluoro-6-nitro-4-hydroxyquinazoline be shipped internationally?

Yes. 7-Fluoro-6-nitro-4-hydroxyquinazoline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.