Afatinib

Name: Afatinib
Brand: Vaqora Chemicals
SKU: VQ-024153

About Afatinib

Vaqora Chemicals supplies Afatinib, a high-purity reference standard of Afatinib registered under CAS number 850140-72-6. With the molecular formula C24H25ClFN5O3, it has a molar mass of 485.9 g/mol. Systematically, it is named (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide. Alternative names: BIBW 2992 and BIBW-2992.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Afatinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Afatinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib
Catalogue No.	VQ-024153
CAS Number	850140-72-6
IUPAC name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular formula	C₂₄H₂₅ClFN₅O₃
Molecular weight	485.9 g/mol
Exact mass	485.163
Grade	Reference Standard
HSN code	38229090
InChIKey	ULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
PubChem CID	10184653

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 8
TPSA	88.6 Å²
Synonyms	BIBW 2992, BIBW-2992, (E/Z)-Afatinib, Afatinib (BIBW2992), Afatinib free base, Afatinib, Free Base, BIBW2992 (Tovok), Afatinib E-Isomer, (S)-Afatinib, BIBW2992,Afatinib, Afatinib - Bio-X trade mark

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib?

The CAS Registry Number of Afatinib is 850140-72-6. It is also known as BIBW 2992, BIBW-2992, (E/Z)-Afatinib.

What is the molecular formula and molecular weight of Afatinib?

Afatinib has the molecular formula C24H25ClFN5O3 and a molecular weight of 485.9 g/mol. Its IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide.

What is Afatinib used for?

Afatinib is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib can I order?

We supply Afatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib?

Yes. Every lot of Afatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib be shipped internationally?

Yes. Afatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.