8-Epitacrolimus

Name: 8-Epitacrolimus
Brand: Vaqora Chemicals
SKU: VQ-028168

About 8-Epitacrolimus

8-Epitacrolimus is an impurity of Tacrolimus carrying the CAS registry number 129212-35-7. Formula C44H69NO12, molecular weight 804.0 g/mol. It is also known as Tacrolimus anhydrous 8-epimer.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Tacrolimus, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 8-Epitacrolimus in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Tacrolimus

View every impurity, metabolite and intermediate we list for Tacrolimus.

Tacrolimus impurities

Specifications & identifiers

Chemical identifiers
Product name	8-Epitacrolimus
Catalogue No.	VQ-028168
CAS Number	129212-35-7
IUPAC name	(1R,9S,12S,13R,14S,17S,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Molecular formula	C₄₄H₆₉NO₁₂
Molecular weight	804 g/mol
Exact mass	803.482
Grade	Reference Standard
HSN code	38229090
InChIKey	QJJXYPPXXYFBGM-NCGCDJFJSA-N
SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
PubChem CID	13006299

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	3 / 12
TPSA	178 Å²

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 8-Epitacrolimus?

The CAS Registry Number of 8-Epitacrolimus is 129212-35-7. It is also known as Tacrolimus anhydrous 8-epimer.

What is the molecular formula and molecular weight of 8-Epitacrolimus?

8-Epitacrolimus has the molecular formula C44H69NO12 and a molecular weight of 804 g/mol.

What is 8-Epitacrolimus used for?

8-Epitacrolimus is supplied as a characterised reference material related to Tacrolimus. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 8-Epitacrolimus can I order?

We supply 8-Epitacrolimus in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 8-Epitacrolimus?

Yes. Every lot of 8-Epitacrolimus is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 8-Epitacrolimus be shipped internationally?

Yes. 8-Epitacrolimus is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.