Tacrolimus EP Impurity E

Name: Tacrolimus EP Impurity E
Brand: Vaqora Chemicals
SKU: VQ-028164

About Tacrolimus EP Impurity E

Listed under CAS 104987-30-6, Tacrolimus EP Impurity E is a pharmacopeial impurity of Tacrolimus available from Vaqora Chemicals. The compound has the formula C44H71NO12, corresponding to a molecular weight of 806.0 g/mol. It is also known as Tacrolimus 8-Propyl Analog or Tacrolimus Monohydrate - Impurity E.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Tacrolimus to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Tacrolimus EP Impurity E in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Tacrolimus

View every impurity, metabolite and intermediate we list for Tacrolimus.

Tacrolimus impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Tacrolimus EP Impurity E
Catalogue No.	VQ-028164
CAS Number	104987-30-6
IUPAC name	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-propyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Molecular formula	C₄₄H₇₁NO₁₂
Molecular weight	806 g/mol
Exact mass	805.4976
Grade	Reference Standard
HSN code	38229090
InChIKey	RQYGKZGKXDOUEO-LFZNUXCKSA-N
SMILES	CCC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C
PubChem CID	13819087

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	3 / 12
TPSA	178 Å²
Synonyms	Tacrolimus 8-Propyl Analog, Tacrolimus Monohydrate - Impurity E, Tsukubamycin B, Dihydro-FK-506, Dihydro-fk-506, (-)-, Dihydro FK-506

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H330Fatal if inhaled

Precautionary statements: P260, P262, P264, P270, P271, P280, P284, P301 + P316, P302 + P352, P304 + P340, P316, P320, P321, P330, P361 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tacrolimus EP Impurity E?

The CAS Registry Number of Tacrolimus EP Impurity E is 104987-30-6. It is also known as Tacrolimus 8-Propyl Analog, Tacrolimus Monohydrate - Impurity E, Tsukubamycin B.

What is the molecular formula and molecular weight of Tacrolimus EP Impurity E?

Tacrolimus EP Impurity E has the molecular formula C44H71NO12 and a molecular weight of 806 g/mol.

What is Tacrolimus EP Impurity E used for?

Tacrolimus EP Impurity E is supplied as a characterised reference material related to Tacrolimus. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tacrolimus EP Impurity E can I order?

We supply Tacrolimus EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tacrolimus EP Impurity E?

Yes. Every lot of Tacrolimus EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tacrolimus EP Impurity E be shipped internationally?

Yes. Tacrolimus EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.