Afatinib Impurity AFT-8

Name: Afatinib Impurity AFT-8
Brand: Vaqora Chemicals
SKU: VQ-020749

About Afatinib Impurity AFT-8

Afatinib Impurity AFT-8 is a metabolite or degradation product of Afatinib carrying the CAS registry number 2323570-72-3. The compound has the formula C24H27ClFN5O4, corresponding to a molecular weight of 504.0 g/mol. Its systematic (IUPAC) name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)-3-hydroxybutanamide. Alternative names: Afatinib Hydroxybutanamide Impurity and Afatinib impurity 44.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Afatinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Afatinib Impurity AFT-8 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Impurity AFT-8
Catalogue No.	VQ-020749
CAS Number	2323570-72-3
IUPAC name	N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)-3-hydroxybutanamide
Molecular formula	C₂₄H₂₇ClFN₅O₄
Molecular weight	504 g/mol
Exact mass	503.1736
Grade	Reference Standard
HSN code	38229090
InChIKey	IQINQKMQCQYKAD-LYKKTTPLSA-N
SMILES	CN(C)CC(CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)O
PubChem CID	163197455

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	3 / 9
TPSA	109 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Impurity AFT-8?

The CAS Registry Number of Afatinib Impurity AFT-8 is 2323570-72-3. It is also known as Afatinib Hydroxybutanamide Impurity, Afatinib impurity 44.

What is the molecular formula and molecular weight of Afatinib Impurity AFT-8?

Afatinib Impurity AFT-8 has the molecular formula C24H27ClFN5O4 and a molecular weight of 504 g/mol. Its IUPAC name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)-3-hydroxybutanamide.

What is Afatinib Impurity AFT-8 used for?

Afatinib Impurity AFT-8 is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Impurity AFT-8 can I order?

We supply Afatinib Impurity AFT-8 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Impurity AFT-8?

Yes. Every lot of Afatinib Impurity AFT-8 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Impurity AFT-8 be shipped internationally?

Yes. We export Afatinib Impurity AFT-8 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.