Afatinib Impurity C

Name: Afatinib Impurity C
Brand: Vaqora Chemicals
SKU: VQ-020745

About Afatinib Impurity C

Afatinib Impurity C is an impurity of Afatinib carrying the CAS registry number 945553-91-3. With the molecular formula C24H25ClFN5O3, it has a molar mass of 485.9 g/mol. Systematically, it is named (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide. Alternative names: (R)-Afatinib and Afatinib R Isomer.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Impurity C
Catalogue No.	VQ-020745
CAS Number	945553-91-3
IUPAC name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular formula	C₂₄H₂₅ClFN₅O₃
Molecular weight	485.9 g/mol
Exact mass	485.163
Grade	Reference Standard
HSN code	38229090
InChIKey	ULXXDDBFHOBEHA-QDLOVBKTSA-N
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4CCOC4
PubChem CID	10163178

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 8
TPSA	88.6 Å²
Synonyms	(R)-Afatinib, Afatinib R Isomer, Afatinib (R)-Isomer, Afatinib, (R)-, R-afatinib, Afatinib Impurity 3, Afatinib Impurity 130, (R)-Afatinib(R)-BIBW 2992

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Impurity C?

The CAS Registry Number of Afatinib Impurity C is 945553-91-3. It is also known as (R)-Afatinib, Afatinib R Isomer, Afatinib (R)-Isomer.

What is the molecular formula and molecular weight of Afatinib Impurity C?

Afatinib Impurity C has the molecular formula C24H25ClFN5O3 and a molecular weight of 485.9 g/mol. Its IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide.

What is Afatinib Impurity C used for?

Afatinib Impurity C is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Impurity C can I order?

We supply Afatinib Impurity C in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Impurity C?

Yes. Every lot of Afatinib Impurity C is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Impurity C be shipped internationally?

Yes. We export Afatinib Impurity C worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.