D-Thyroxine

Name: D-Thyroxine
Brand: Vaqora Chemicals
SKU: VQ-032476

About D-Thyroxine

Vaqora Chemicals supplies D-Thyroxine, an impurity of Levothyroxine registered under CAS number 51-49-0. With the molecular formula C15H11I4NO4, it has a molar mass of 776.87 g/mol. Its systematic (IUPAC) name is (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid. It is also known as Dextrothyroxine or Choloxin.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Levothyroxine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer D-Thyroxine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Levothyroxine

View every impurity, metabolite and intermediate we list for Levothyroxine.

Levothyroxine impurities

Specifications & identifiers

Chemical identifiers
Product name	D-Thyroxine
Catalogue No.	VQ-032476
CAS Number	51-49-0
IUPAC name	(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Molecular formula	C₁₅H₁₁I₄NO₄
Molecular weight	776.87 g/mol
Exact mass	776.6867
Grade	Reference Standard
HSN code	38229090
InChIKey	XUIIKFGFIJCVMT-GFCCVEGCSA-N
SMILES	C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)O)N
PubChem CID	8730

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	3 / 5
TPSA	92.8 Å²
Synonyms	Dextrothyroxine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine, (2R)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid, (R)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid, Choloxin, D-T4, D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, Biotirmone, (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic aci d, (R)-2-Amino-3-(4-(4-hydroxy-35-diiodophenoxy)-35-diiodophenyl)propanoic acid, D-4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzylalanine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements: P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of D-Thyroxine?

The CAS Registry Number of D-Thyroxine is 51-49-0. It is also known as Dextrothyroxine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine, (2R)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid.

What is the molecular formula and molecular weight of D-Thyroxine?

D-Thyroxine has the molecular formula C15H11I4NO4 and a molecular weight of 776.87 g/mol. Its IUPAC name is (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid.

What is D-Thyroxine used for?

D-Thyroxine is supplied as a characterised reference material related to Levothyroxine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of D-Thyroxine can I order?

We supply D-Thyroxine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with D-Thyroxine?

Yes. Every lot of D-Thyroxine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can D-Thyroxine be shipped internationally?

Yes. D-Thyroxine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.