Levothyroxine EP Impurity K

Name: Levothyroxine EP Impurity K
Brand: Vaqora Chemicals
SKU: VQ-034856

About Levothyroxine EP Impurity K

Levothyroxine EP Impurity K is a pharmacopeial impurity of Levothyroxine carrying the CAS registry number 5817-39-0. Its molecular formula is C15H12I3NO4 and its molecular weight is 650.97 g/mol. Its systematic (IUPAC) name is (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid. Common synonyms include Levothyroxine - Impurity K and 3,3',5'-Triiodo-L-thyronine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Levothyroxine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Levothyroxine

View every impurity, metabolite and intermediate we list for Levothyroxine.

Levothyroxine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Levothyroxine EP Impurity K
Catalogue No.	VQ-034856
CAS Number	5817-39-0
IUPAC name	(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
Molecular formula	C₁₅H₁₂I₃NO₄
Molecular weight	650.97 g/mol
Exact mass	650.7901
Grade	Reference Standard
HSN code	38229090
InChIKey	HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES	C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
PubChem CID	644280

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	3 / 5
TPSA	92.8 Å²
Synonyms	Levothyroxine - Impurity K, 3,3',5'-Triiodo-L-thyronine, Reverse T3, Triiodothyronine, reverse, L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-, 3',5',3-Triiodothyronine, 3,3,5 Triiodothyronine, 3,3,5-Triiodothyronine, 4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenylalanine, 3,3',5'-Triiodothyronine, (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid, Isoliothyronine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements: P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Levothyroxine EP Impurity K?

The CAS Registry Number of Levothyroxine EP Impurity K is 5817-39-0. It is also known as Levothyroxine - Impurity K, 3,3',5'-Triiodo-L-thyronine, Reverse T3.

What is the molecular formula and molecular weight of Levothyroxine EP Impurity K?

Levothyroxine EP Impurity K has the molecular formula C15H12I3NO4 and a molecular weight of 650.97 g/mol. Its IUPAC name is (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid.

What is Levothyroxine EP Impurity K used for?

Levothyroxine EP Impurity K is supplied as a characterised reference material related to Levothyroxine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Levothyroxine EP Impurity K can I order?

We supply Levothyroxine EP Impurity K in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Levothyroxine EP Impurity K?

Yes. Every lot of Levothyroxine EP Impurity K is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Levothyroxine EP Impurity K be shipped internationally?

Yes. Levothyroxine EP Impurity K is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.