Diltiazem EP Impurity B

Name: Diltiazem EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-006329

About Diltiazem EP Impurity B

Diltiazem EP Impurity B (CAS 87447-47-0) is a pharmacopeial impurity of Diltiazem offered by Vaqora Chemicals with a typical assay of 98.56%. Formula C18H17NO4S, molecular weight 343.4 g/mol. Its systematic (IUPAC) name is [(2S,3S)-2-(4-methoxyphenyl)-4-oxo-3,5-dihydro-2H-1,5-benzothiazepin-3-yl] acetate. It is also known as Des[5-(2-dimethylamino)ethyl] Diltiazem or Acetoxy Lactam Diltiazem.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Diltiazem to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Diltiazem EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Diltiazem

View every impurity, metabolite and intermediate we list for Diltiazem.

Diltiazem impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Diltiazem EP Impurity B
Catalogue No.	VQ-006329
CAS Number	87447-47-0
IUPAC name	[(2S,3S)-2-(4-methoxyphenyl)-4-oxo-3,5-dihydro-2H-1,5-benzothiazepin-3-yl] acetate
Molecular formula	C₁₈H₁₇NO₄S
Molecular weight	343.4 g/mol
Exact mass	343.0878
Grade	Reference Standard
Purity / assay	98.56%
HSN code	38229090
InChIKey	WKLRIRQZTCFCSE-SJORKVTESA-N
SMILES	CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2NC1=O)C3=CC=C(C=C3)OC
PubChem CID	11110671

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	1 / 5
TPSA	89.9 Å²
Synonyms	(2S,3S)-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, (2S-cis)-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-Benzothiazepin-4(5H)-one, (2S ,3S )-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-3-yl acetate, Des[5-(2-dimethylamino)ethyl] Diltiazem, Acetoxy Lactam Diltiazem, Diltiazem related compound B (USP), (2S)-cis-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, (2S,3S)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl Acetate, (2S,3S)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate, 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-, (2S,3S)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-ylacetate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diltiazem EP Impurity B?

The CAS Registry Number of Diltiazem EP Impurity B is 87447-47-0. It is also known as (2S,3S)-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, (2S-cis)-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-Benzothiazepin-4(5H)-one, (2S ,3S )-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-3-yl acetate.

What is the molecular formula and molecular weight of Diltiazem EP Impurity B?

Diltiazem EP Impurity B has the molecular formula C18H17NO4S and a molecular weight of 343.4 g/mol. Its IUPAC name is [(2S,3S)-2-(4-methoxyphenyl)-4-oxo-3,5-dihydro-2H-1,5-benzothiazepin-3-yl] acetate.

What is Diltiazem EP Impurity B used for?

Diltiazem EP Impurity B is supplied as a characterised reference material related to Diltiazem. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diltiazem EP Impurity B can I order?

We supply Diltiazem EP Impurity B in Reference Standard (98.56%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diltiazem EP Impurity B?

Yes. Every lot of Diltiazem EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diltiazem EP Impurity B be shipped internationally?

Yes. Diltiazem EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.