Hydroxyzine Hydrochloride

Name: Hydroxyzine Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-004174

About Hydroxyzine Hydrochloride

Hydroxyzine Hydrochloride (CAS 2192-20-3) is a respiratory / antiallergic API offered by Vaqora Chemicals in IP/BP/USP grade. The compound has the formula C21H29Cl3N2O2, corresponding to a molecular weight of 447.8 g/mol. The IUPAC name is 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol. Dihydrochloride. It is also known as Hydroxyzine dihydrochloride or Hydroxyzine Hcl.

In its supplied form it is a white or similar white powder odorless. Keep the container tightly sealed and store it in a cool, dry area. It carries the GHS signal word “Danger” with 7 hazard statements. Review the Safety Data Sheet before use.

As an active pharmaceutical ingredient within our respiratory and antiallergic APIs range, it is offered in IP/BP/USP grade for formulation development, generic drug programmes and commercial manufacturing. Buyers come mainly from pharmaceutical manufacturing.

Standard pack sizes are 1 kg, 5 kg and 25 kg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmaceutical formulation
Generic drug development

Industries

Related to Hydroxyzine

View every impurity, metabolite and intermediate we list for Hydroxyzine.

Hydroxyzine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Hydroxyzine Hydrochloride
Catalogue No.	VQ-004174
CAS Number	2192-20-3
IUPAC name	2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
Molecular formula	C₂₁H₂₉Cl₃N₂O₂
Molecular weight	447.8 g/mol
Exact mass	446.1295
Grade	IP/BP/USP
HSN code	2933
InChIKey	ANOMHKZSQFYSBR-UHFFFAOYSA-N
SMILES	C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
PubChem CID	91513

Physical properties
Physical form	Powder
Appearance	White or similar white powder odorless
H-bond donors / acceptors	3 / 4
TPSA	35.9 Å²
Synonyms	Hydroxyzine dihydrochloride, Hydroxyzine Hcl, Atranine A, Atarax dihydrochloride, 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol dihydrochloride, Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-, dihydrochloride, Hyzine-50, 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine hydrochloride, 2-(2-(4-((RS)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride, Hydroxyzine 2HCl, Hydroxyzine DiHCl

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P272, P280, P301 + P317, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P318, P319, P321, P330, P332 + P317, P333 + P317, P337 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Hydroxyzine Hydrochloride?

The CAS Registry Number of Hydroxyzine Hydrochloride is 2192-20-3. It is also known as Hydroxyzine dihydrochloride, Hydroxyzine Hcl, Atranine A.

What is the molecular formula and molecular weight of Hydroxyzine Hydrochloride?

Hydroxyzine Hydrochloride has the molecular formula C21H29Cl3N2O2 and a molecular weight of 447.8 g/mol.

What is Hydroxyzine Hydrochloride used for?

Hydroxyzine Hydrochloride is supplied as a characterised reference material related to Hydroxyzine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Hydroxyzine Hydrochloride can I order?

We supply Hydroxyzine Hydrochloride in IP/BP/USP grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Hydroxyzine Hydrochloride?

Yes. Every lot of Hydroxyzine Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Hydroxyzine Hydrochloride be shipped internationally?

Yes. Hydroxyzine Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.