Isosorbide Dinitrate EP Impurity B

Name: Isosorbide Dinitrate EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-022870

About Isosorbide Dinitrate EP Impurity B

Isosorbide Dinitrate EP Impurity B (CAS 16106-20-0) is a pharmacopeial impurity of Isosorbide offered by Vaqora Chemicals. The compound has the formula C6H9NO6, corresponding to a molecular weight of 191.14 g/mol. The IUPAC name is [(3R,3aR,6S,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate. Common synonyms include Isosorbide-2-Mononitrate and Isosorbide-2-nitrate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Isosorbide to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Isosorbide

View every impurity, metabolite and intermediate we list for Isosorbide.

Isosorbide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Isosorbide Dinitrate EP Impurity B
Catalogue No.	VQ-022870
CAS Number	16106-20-0
IUPAC name	[(3R,3aR,6S,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
Molecular formula	C₆H₉NO₆
Molecular weight	191.14 g/mol
Exact mass	191.043
Grade	Reference Standard
HSN code	38229090
InChIKey	YWXYYJSYQOXTPL-JGWLITMVSA-N
SMILES	C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O[N+](=O)[O-])O
PubChem CID	62989

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.4
H-bond donors / acceptors	1 / 6
TPSA	93.7 Å²
Synonyms	Isosorbide-2-Mononitrate, Isosorbide-2-nitrate, Isosorbide Dinitrate EP Impurity A, Isosorbide Mononitrate EP Impurity B, Isosorbide - Impurity B, Isosorbide 2-Nitrate (In lactose), Isosorbide 2-nitrate, Isosorbide 2-mononitrate, isosorbide nitrate, D-Glucitol, 1,4:3,6-dianhydro-, 2-nitrate, 1,4:3,6-Dianhydro-D-glucitol 2-nitrate, (3S,3aS,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate

Safety & hazard information (GHS)

Flammable

Harmful / irritant

Signal word: Danger

Hazard statements

H242Heating may cause a fire
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P210, P234, P235, P240, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P370 + P378, P403, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Isosorbide Dinitrate EP Impurity B?

The CAS Registry Number of Isosorbide Dinitrate EP Impurity B is 16106-20-0. It is also known as Isosorbide-2-Mononitrate, Isosorbide-2-nitrate, Isosorbide Dinitrate EP Impurity A.

What is the molecular formula and molecular weight of Isosorbide Dinitrate EP Impurity B?

Isosorbide Dinitrate EP Impurity B has the molecular formula C6H9NO6 and a molecular weight of 191.14 g/mol. Its IUPAC name is [(3R,3aR,6S,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate.

What is Isosorbide Dinitrate EP Impurity B used for?

Isosorbide Dinitrate EP Impurity B is supplied as a characterised reference material related to Isosorbide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Isosorbide Dinitrate EP Impurity B can I order?

We supply Isosorbide Dinitrate EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Isosorbide Dinitrate EP Impurity B?

Yes. Every lot of Isosorbide Dinitrate EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Isosorbide Dinitrate EP Impurity B be shipped internationally?

Yes. Isosorbide Dinitrate EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.