Methotrexate

Name: Methotrexate
Brand: Vaqora Chemicals
SKU: VQ-007576

About Methotrexate

Methotrexate is a high-purity reference standard of Methotrexate carrying the CAS registry number 59-05-2. Formula C20H22N8O5, molecular weight 454.4 g/mol. Systematically, it is named (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. Common synonyms include (+)-Amethopterin and 4-Amino-10-methylfolic acid.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Methotrexate, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Methotrexate in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate
Catalogue No.	VQ-007576
CAS Number	59-05-2
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molecular weight	454.4 g/mol
Exact mass	454.1713
Grade	Reference Standard
HSN code	38229090
InChIKey	FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	126941

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.8
H-bond donors / acceptors	5 / 12
TPSA	211 Å²
Synonyms	N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, (+)-Amethopterin, (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylfolic Acid, Antifolan, Emtexate, Ledertrexate, MTX, L-Metatrexan, Methylaminopterin, Mexate

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 59-05-2

IP/BP/USP

Methotrexate

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-004219

Methotrexate, 98%

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-011980

Frequently asked questions

What is the CAS number of Methotrexate?

The CAS Registry Number of Methotrexate is 59-05-2. It is also known as N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, (+)-Amethopterin, (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid.

What is the molecular formula and molecular weight of Methotrexate?

Methotrexate has the molecular formula C20H22N8O5 and a molecular weight of 454.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

What is Methotrexate used for?

Methotrexate is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate can I order?

We supply Methotrexate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate?

Yes. Every lot of Methotrexate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate be shipped internationally?

Yes. Methotrexate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.