Methotrexate

Name: Methotrexate
Brand: Vaqora Chemicals
SKU: VQ-004219

About Methotrexate

Methotrexate is an anticancer API (IP/BP/USP grade) carrying the CAS registry number 59-05-2 at a purity of 99.6%. The compound has the formula C20H22N8O5, corresponding to a molecular weight of 454.4 g/mol. Its systematic (IUPAC) name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. Alternative names: Amethopterin and Ledertrexate.

The material typically appears as a yellow crystalline powder (Results: conforms). Store sealed in a dry, well-ventilated location away from incompatible materials. It carries the GHS signal word “Danger” with 5 hazard statements. Review the Safety Data Sheet before use.

As an active pharmaceutical ingredient within our oncology APIs range, it is offered in IP/BP/USP grade for formulation development, generic drug programmes and commercial manufacturing. It is used across pharmaceutical manufacturing.

We offer Methotrexate in 1 kg, 5 kg and 25 kg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Polymer & resin production
Pharmaceutical formulation

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate
Catalogue No.	VQ-004219
CAS Number	59-05-2
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molecular weight	454.4 g/mol
Exact mass	454.1713
Grade	IP/BP/USP
Purity / assay	99.6%
HSN code	2933
InChIKey	FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	126941

Physical properties
Physical form	Powder
Appearance	Yellow crystalline powder (Results: conforms)
LogP (XLogP3)	-1.8
H-bond donors / acceptors	5 / 12
TPSA	211 Å²
Synonyms	Amethopterin, Ledertrexate, Emtexate, L-Amethopterin, Amethopterine, Medsatrexate, Methoblastin, Methotextrate, Brimexate, Emthexate, Texate, EMT 25,299

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 59-05-2

Reference Standard

Methotrexate

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-007576

Methotrexate, 98%

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-011980

Frequently asked questions

What is the CAS number of Methotrexate?

The CAS Registry Number of Methotrexate is 59-05-2. It is also known as Amethopterin, Ledertrexate, Emtexate.

What is the molecular formula and molecular weight of Methotrexate?

Methotrexate has the molecular formula C20H22N8O5 and a molecular weight of 454.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

What is Methotrexate used for?

Methotrexate is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate can I order?

We supply Methotrexate in IP/BP/USP (99.6%) grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate?

Yes. Every lot of Methotrexate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate be shipped internationally?

Yes. Methotrexate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.