N-Nitroso Nebivolol (Mixture of Diastereomers) 1391051-68-5

Name: N-Nitroso Nebivolol (Mixture of Diastereomers)
Brand: Vaqora Chemicals
SKU: VQ-023218

About N-Nitroso Nebivolol (Mixture of Diastereomers)

Vaqora Chemicals supplies N-Nitroso Nebivolol (Mixture of Diastereomers), a nitrosamine impurity of Nebivolol registered under CAS number 1391051-68-5. Its molecular formula is C22H24F2N2O5 and its molecular weight is 434.4 g/mol. Systematically, it is named N,N-bis[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]nitrous amide. Alternative names: N-Nitroso-Nebivolol and N-Nitroso Nebivolol.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Nebivolol, method validation (AMV) and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Nitroso Nebivolol (Mixture of Diastereomers) in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Nebivolol (Mixture of Diastereomers)
Catalogue No.	VQ-023218
CAS Number	1391051-68-5
IUPAC name	N,N-bis[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]nitrous amide
Molecular formula	C₂₂H₂₄F₂N₂O₅
Molecular weight	434.4 g/mol
Exact mass	434.1653
Grade	Reference Standard
HSN code	38229090
InChIKey	TXDRIMZKXCWKRC-UHFFFAOYSA-N
SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CN(CC(C3CCC4=C(O3)C=CC(=C4)F)O)N=O)O
PubChem CID	71751137

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 9
TPSA	91.6 Å²
Synonyms	N-Nitroso-Nebivolol, N-Nitroso Nebivolol, N,N-Bis(2-(6-fluorochroman-2-yl)-2-hydroxyethyl)nitrous amide, N-Nitrosonebivolol, N,N-Bis[2-(6-fluoro-2-chromanyl)-2-hydroxyethyl]nitrous Amide, N,N-bis[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]nitrous amide

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Nebivolol (Mixture of Diastereomers)?

The CAS Registry Number of N-Nitroso Nebivolol (Mixture of Diastereomers) is 1391051-68-5. It is also known as N-Nitroso-Nebivolol, N-Nitroso Nebivolol, N,N-Bis(2-(6-fluorochroman-2-yl)-2-hydroxyethyl)nitrous amide.

What is the molecular formula and molecular weight of N-Nitroso Nebivolol (Mixture of Diastereomers)?

N-Nitroso Nebivolol (Mixture of Diastereomers) has the molecular formula C22H24F2N2O5 and a molecular weight of 434.4 g/mol. Its IUPAC name is N,N-bis[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]nitrous amide.

What is N-Nitroso Nebivolol (Mixture of Diastereomers) used for?

N-Nitroso Nebivolol (Mixture of Diastereomers) is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Nebivolol (Mixture of Diastereomers) can I order?

We supply N-Nitroso Nebivolol (Mixture of Diastereomers) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Nebivolol (Mixture of Diastereomers)?

Yes. Every lot of N-Nitroso Nebivolol (Mixture of Diastereomers) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Nebivolol (Mixture of Diastereomers) be shipped internationally?

Yes. N-Nitroso Nebivolol (Mixture of Diastereomers) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.