Sacubitril Impurity 22

Name: Sacubitril Impurity 22
Brand: Vaqora Chemicals
SKU: VQ-005857

About Sacubitril Impurity 22

Sacubitril Impurity 22 (CAS 1012341-48-8) is an impurity of Sacubitril offered by Vaqora Chemicals. The compound has the formula C23H27NO4, corresponding to a molecular weight of 381.5 g/mol. The IUPAC name is (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid. Common synonyms include LCZ-696 Impurity 58 and Sacubitril Impurity I. Valsartan Impurity 28.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

As a characterised impurity of Sacubitril, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	Sacubitril Impurity 22
Catalogue No.	VQ-005857
CAS Number	1012341-48-8
IUPAC name	(E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid
Molecular formula	C₂₃H₂₇NO₄
Molecular weight	381.5 g/mol
Exact mass	381.194
Grade	Reference Standard
HSN code	38229090
InChIKey	JXTNUXJSXXIIFE-VISDOYDDSA-N
SMILES	C/C(=C\[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)OC(C)(C)C)/C(=O)O
PubChem CID	56846981

Physical properties
Physical form	Solid
LogP (XLogP3)	4.7
H-bond donors / acceptors	2 / 4
TPSA	75.6 Å²
Synonyms	(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid, (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid, LCZ-696 Impurity 58, (E,4R)-4-(tert-butoxycarbonylamino)-2-methyl-5-(4-phenylphenyl)pent-2-enoic acid, Sacubitril Impurity I, Valsartan Impurity 28, (R,E)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methyl-2-pentenoic Acid, (2E,4R)-4-{[(tert-butoxy)carbonyl]amino}-2-methyl-5-(4-phenylphenyl)pent-2-enoic acid, (E)-(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid, (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid, (2E,4R)-5-([1,1'-Biphenyl]-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpent-2-enoic acid, (2E,4R)-5-{[1,1-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

Safety & hazard information (GHS)

Environmental hazard

Hazard statements

H411Toxic to aquatic life with long lasting effects
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sacubitril Impurity 22?

The CAS Registry Number of Sacubitril Impurity 22 is 1012341-48-8. It is also known as (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid, (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid, LCZ-696 Impurity 58.

What is the molecular formula and molecular weight of Sacubitril Impurity 22?

Sacubitril Impurity 22 has the molecular formula C23H27NO4 and a molecular weight of 381.5 g/mol. Its IUPAC name is (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid.

What is Sacubitril Impurity 22 used for?

Sacubitril Impurity 22 is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sacubitril Impurity 22 can I order?

We supply Sacubitril Impurity 22 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sacubitril Impurity 22?

Yes. Every lot of Sacubitril Impurity 22 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sacubitril Impurity 22 be shipped internationally?

Yes. Sacubitril Impurity 22 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.