Topotecan Hydrochloride

Name: Topotecan Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-034363

About Topotecan Hydrochloride

Topotecan Hydrochloride is a high-purity reference standard of Topotecan carrying the CAS registry number 119413-54-6. Its molecular formula is C23H24ClN3O5 and its molecular weight is 457.9 g/mol. Common synonyms include Topotecan Hcl and Nogitecan hydrochloride.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Topotecan standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Topotecan Hydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Topotecan

View every impurity, metabolite and intermediate we list for Topotecan.

Topotecan impurities

Specifications & identifiers

Chemical identifiers
Product name	Topotecan Hydrochloride
Catalogue No.	VQ-034363
CAS Number	119413-54-6
IUPAC name	(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
Molecular formula	C₂₃H₂₄ClN₃O₅
Molecular weight	457.9 g/mol
Exact mass	457.1404
Grade	Reference Standard
HSN code	38229090
InChIKey	DGHHQBMTXTWTJV-BQAIUKQQSA-N
SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
PubChem CID	60699

Physical properties
Physical form	Solid
H-bond donors / acceptors	3 / 7
TPSA	103 Å²
Synonyms	Topotecan Hcl, Nogitecan hydrochloride, Evotopin, Topotecan teva, Topotecan Actavis, Topotecan Hospira, potactasol, Topotecan (as hydrochloride), Hydrochloride, Nogitecan, Hydrochloride, Topotecan, topotecan hydrochloride (oral), Topotecan Monohydrochloride, (S)-

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H301Toxic if swallowed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P308 + P316, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Topotecan Hydrochloride?

The CAS Registry Number of Topotecan Hydrochloride is 119413-54-6. It is also known as Topotecan Hcl, Nogitecan hydrochloride, Evotopin.

What is the molecular formula and molecular weight of Topotecan Hydrochloride?

Topotecan Hydrochloride has the molecular formula C23H24ClN3O5 and a molecular weight of 457.9 g/mol.

What is Topotecan Hydrochloride used for?

Topotecan Hydrochloride is supplied as a characterised reference material related to Topotecan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Topotecan Hydrochloride can I order?

We supply Topotecan Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Topotecan Hydrochloride?

Yes. Every lot of Topotecan Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Topotecan Hydrochloride be shipped internationally?

Yes. Topotecan Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.