Desmethyl Dabrafenib

About Desmethyl Dabrafenib

Desmethyl Dabrafenib is a metabolite or degradation product of Dabrafenib carrying the CAS registry number 1195765-47-9. Its molecular formula is C22H18F3N5O2S2 and its molecular weight is 505.5 g/mol. Its systematic (IUPAC) name is N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide. Common synonyms include Dabrafenib metabolite M8.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Dabrafenib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Desmethyl Dabrafenib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Dabrafenib

View every impurity, metabolite and intermediate we list for Dabrafenib.

Dabrafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Desmethyl Dabrafenib
Catalogue No.	VQ-022296
CAS Number	1195765-47-9
IUPAC name	N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Molecular formula	C₂₂H₁₈F₃N₅O₂S₂
Molecular weight	505.5 g/mol
Exact mass	505.0854
Grade	Reference Standard
HSN code	38229090
InChIKey	MQEHPCURISZMGR-UHFFFAOYSA-N
SMILES	CC(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
PubChem CID	58345847

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	2 / 11
TPSA	147 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Desmethyl Dabrafenib?

The CAS Registry Number of Desmethyl Dabrafenib is 1195765-47-9. It is also known as Dabrafenib metabolite M8.

What is the molecular formula and molecular weight of Desmethyl Dabrafenib?

Desmethyl Dabrafenib has the molecular formula C22H18F3N5O2S2 and a molecular weight of 505.5 g/mol. Its IUPAC name is N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide.

What is Desmethyl Dabrafenib used for?

Desmethyl Dabrafenib is supplied as a characterised reference material related to Dabrafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Desmethyl Dabrafenib can I order?

We supply Desmethyl Dabrafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Desmethyl Dabrafenib?

Yes. Every lot of Desmethyl Dabrafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Desmethyl Dabrafenib be shipped internationally?

Yes. We export Desmethyl Dabrafenib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.